RECRUITING

STICH3C Cardiac Magnetic Resonance Observational Study

Description

STICOS will test the hypothesis that residual jeopardized myocardium, late gadolinium enhancement, and non-ischemic substrate after revascularization is associated with postoperative adverse cardiovascular events such as heart failure , readmission, or death. This study will look at whether certain heart tissue abnormalities seen on MRI scans can help predict serious health problems after heart procedures like stents or bypass surgery.

Conditions

Ischemic Left Ventricle Systolic DysfunctionMultivessel Coronary Artery Disease
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Related Conditions:

Ischemic Left Ventricle Systolic DysfunctionMultivessel Coronary Artery Disease

Study Overview

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Study Details

Study overview

STICOS will test the hypothesis that residual jeopardized myocardium, late gadolinium enhancement, and non-ischemic substrate after revascularization is associated with postoperative adverse cardiovascular events such as heart failure , readmission, or death. This study will look at whether certain heart tissue abnormalities seen on MRI scans can help predict serious health problems after heart procedures like stents or bypass surgery.

STICH3C Cardiac Magnetic Resonance (CMR) Observational Study (STICOS)

STICH3C Cardiac Magnetic Resonance Observational Study

Condition
Ischemic Left Ventricle Systolic Dysfunction
Intervention / Treatment

-

Contacts and Locations

Brooklyn

NewYork-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, United States, 11215

Flushing

New York Presbyterian - Queens, Flushing, New York, United States, 11355

New York

Weill Cornell Medicine/NewYork Presbyterian Hospital, New York, New York, United States, 10022

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Men and women ≥ 18 years old
  • 2. LVEF ≤ 40% (quantified by echo, single-photon emission computed tomography \[SPECT\], or CMR within 2 months of enrollment)
  • 3. Prognostically important CAD: either multivessel CAD (triple vessel or double vessel CAD including left anterior descendant artery (LAD), significant coronary stenosis defined as ≥ 70% based on coronary angiography, fractional flow reserve (FFR) ≤ 0.80 or instantaneous wave-free ratio (iFR) ≤ 0.89) or left main disease (+/- other CAD) for which significant stenosis defined as \> 50% based on coronary angiography, intravascular ultrasound (IVUS) minimum luminal area \[MLA\] value ≤ 6.0 mm2 (\< 4.5 mm2 Asian descent), or equivalent optical coherence tomography (OCT) measurements.
  • 4. Planned CABG or PCI within 3 months
  • 1. Concomitant valve disease or other condition (e.g., LV aneurysm) requiring surgical repair or replacement
  • 2. Contraindication to CMR (i.e. magnetically activated materials), gadolinium, regadenoson/adenosine/dipyridamole
  • 3. Active neoplasm and/or severe end-organ dysfunction with expected life expectancy less than 5 years.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Weill Medical College of Cornell University,

Mario Gaudino, MD, PhD, MSCE, FEBCTS, FACC, PRINCIPAL_INVESTIGATOR, Weill Medical College of Cornell University

Study Record Dates

2030-01