RECRUITING

Appetite Response to Meals With Different Protein Sources in Women With PCOS

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by insulin resistance, hyperandrogenism, and reproductive dysfunction. Dietary strategies that improve postprandial insulin and glucose responses are central to managing metabolic symptoms in PCOS. Meals higher in protein can attenuate postprandial glycemia and enhance satiety, but the effects may vary by protein source. Animal sources of protein typically have higher essential amino acid content and insulinogenic potential, whereas plant proteins offer fiber and phytochemicals that may influence glycemic dynamics differently. Few studies have directly compared the acute metabolic effects of plant versus animal protein in women with PCOS. Given the distinct pathophysiology of PCOS, extrapolating findings from healthy populations may be misleading. Understanding protein-specific effects on postprandial insulin, glucose, and appetite-regulating hormones in this group is essential for targeted nutrition guidance. Additionally, plant-based diets are increasingly promoted for cardiometabolic health, but their acute effects in insulin-resistant women remain underexplored. This study will assess whether plant and animal protein meals elicit differential postprandial responses in women with PCOS. Findings may inform dietary recommendations aimed at improving metabolic outcomes in this high-risk population.

Official Title

Comparative Meal Response to Plant vs. Animal Protein in Women With PCOS

Quick Facts

Study Start:2025-08-18
Study Completion:2027-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07142603

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 50 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Females ages 18-50 years
  2. * Confirmed diagnosis of PCOS
  3. * Body mass index (BMI) between 18.5 and 35 kg/m2
  4. * Stable body weight for at least 3 months (+ 5 pounds)
  5. * Willingness to consume both plant- and animal-based protein meals
  1. * Smoking or use of nicotine products
  2. * Smoking or use of marijuana products
  3. * Food allergies or dietary restrictions incompatible with test meals
  4. * Diagnosed diabetes (type 1 or 2)
  5. * Use of medications that interfere with study outcomes (e.g., metformin, GLP-1 agonists, etc.)

Contacts and Locations

Study Contact

Jamie I Baum, PhD
CONTACT
479-575-4474
baum@uark.edu
Sydney Boudrey, MS, RDN
CONTACT
seboudre@uark.edu

Principal Investigator

Jamie I Baum, PhD
PRINCIPAL_INVESTIGATOR
University of Arkansas, Fayetteville

Study Locations (Sites)

Center for Human Nutrition
Fayetteville, Arkansas, 72704
United States

Collaborators and Investigators

Sponsor: University of Arkansas, Fayetteville

  • Jamie I Baum, PhD, PRINCIPAL_INVESTIGATOR, University of Arkansas, Fayetteville

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-08-18
Study Completion Date2027-06-30

Study Record Updates

Study Start Date2025-08-18
Study Completion Date2027-06-30

Terms related to this study

Keywords Provided by Researchers

  • PCOS
  • polycystic ovary syndrome
  • Protein
  • Women

Additional Relevant MeSH Terms

  • Polycystic Ovary Syndrome (PCOS)