RECRUITING

Wildfire Related Air Pollution Exposure and Cognitive Function Pilot Study

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study will examine how breathing wildfire-related air pollution (WRAP) for one hour affects healthy adults. The main question the study will answer if the effect of WRAP exposure on p-tau, a blood marker of cognitive decline. The changes in p-tau concentrations after exposure to WRAP will be compared to the changes in p-tau after exposure to clean air. Participants will: * Have 2 study visits - one visit with exposure to clean air and one visit with exposure to simulated wildfire smoke * Have blood drawn before and after each exposure * Complete cognitive tests and memory tasks before and after each exposure

Official Title

A Controlled Human Environmental Study Evaluating the Impacts of Cognitive Functions During the Exposure of Simulated Wildfire-Related Air Pollution (WRAP).

Quick Facts

Study Start:2025-09-18
Study Completion:2026-10-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07151235

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 40 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Healthy
  2. * Non smoker
  3. * Weight at least 110 pounds
  4. * Between ages 18 and 40 years old
  1. * Claustrophobia or not comfortable in enclosed spaces.
  2. * Colorblindness.
  3. * Inability to hear verbal instructions.
  4. * Cardiovascular disease which, in the opinion of the investigator, would elevate the participant's risk of adverse effects to WRAP exposure. This includes a history of stroke.
  5. * Diabetes requiring the use of insulin.
  6. * Pregnancy (A pregnancy test will be provided to you).
  7. * Current asthma (an asthma attack within the past five years).
  8. * History of childhood asthma.
  9. * Medications which may affect cognition such as beta-blockers and CNS depressants.
  10. * Respiratory symptoms in the previous 4 weeks (cough, wheezing, shortness of breath, etc.) which, in the opinion of the investigator, would elevate the participant's risk of adverse effects to WRAP exposure.
  11. * Use of sedating cold/allergy medications in the previous week.
  12. * Use of marijuana in the previous week.
  13. * Consumption of alcohol in the previous 24 hours.
  14. * Kidney or liver disease.
  15. * Thyroid disease.
  16. * High blood pressure.
  17. * Cancer.
  18. * Parkinson's disease.
  19. * Pacemaker.
  20. * Hay fever.

Contacts and Locations

Study Contact

Kathy Black, PhD
CONTACT
848-445-6049
kgblack@eohsi.rutgers.edu
Adriana De Resende, MPH
CONTACT
848-445-0178
ad998@eohsi.rutgers.edu

Principal Investigator

Jose G Cedeno-Laurent, ScD
PRINCIPAL_INVESTIGATOR
Rutgers, The State University of New Jersey: New Brunswick/Piscataway Campus

Study Locations (Sites)

Rutgers-EOHSI
Piscataway, New Jersey, 08854
United States

Collaborators and Investigators

Sponsor: Rutgers, The State University of New Jersey

  • Jose G Cedeno-Laurent, ScD, PRINCIPAL_INVESTIGATOR, Rutgers, The State University of New Jersey: New Brunswick/Piscataway Campus

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-09-18
Study Completion Date2026-10-01

Study Record Updates

Study Start Date2025-09-18
Study Completion Date2026-10-01

Terms related to this study

Keywords Provided by Researchers

  • wildfires
  • air pollution
  • ultrafine particles
  • cognitive function

Additional Relevant MeSH Terms

  • Healthy Participants