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Personalized Theta-burst Stimulation for Long-lasting Changes in Approach/Avoidance Behavior

Description

This study will assess the long-lasting effects of personalized theta burst stimulation (TBS), a repetitive form of transcranial magnetic stimulation (TMS), over the left prefrontal cortex on the approach/avoidance behavior. TBS will be personalized based on the prefrontal theta rhythm captured with electroencephalography (EEG). The main questions it aims to answer are: 1. does a single session of personalized TBS synchronized with the individual theta rhythm over the left prefrontal cortex results in the outlasting changes in the individual behavior? 2. Does TBS results in the brain rhythms' changes as measured using resting-state EEG?

Conditions

Approach/Avoidance Behavior
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Related Conditions:

Approach/Avoidance Behavior

Study Overview

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Study Details

Study overview

This study will assess the long-lasting effects of personalized theta burst stimulation (TBS), a repetitive form of transcranial magnetic stimulation (TMS), over the left prefrontal cortex on the approach/avoidance behavior. TBS will be personalized based on the prefrontal theta rhythm captured with electroencephalography (EEG). The main questions it aims to answer are: 1. does a single session of personalized TBS synchronized with the individual theta rhythm over the left prefrontal cortex results in the outlasting changes in the individual behavior? 2. Does TBS results in the brain rhythms' changes as measured using resting-state EEG?

The Efficiency of Personalized Theta-burst Stimulation for Inducing Long-lasting Changes in DLPFC

Personalized Theta-burst Stimulation for Long-lasting Changes in Approach/Avoidance Behavior

Condition
Approach/Avoidance Behavior
Intervention / Treatment

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Contacts and Locations

Chicago

Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States, 60611

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Participants must be legal adults between the ages of 18 to 65;
  • 2. Able and willing to complete study procedures and tasks.
  • 1. History or evidence of chronic neurological or mental disorder;
  • 2. Chronic condition that requires pharmacological treatment over the course of study participation;
  • 3. Pregnancy or breastfeeding;
  • 4. History or evidence of alcohol or drug addiction;
  • 5. Contraindications for transcranial magnetic stimulation (history of seizures, metallic or electric implant in the head/neck area);
  • 6. Contraindications for magnetic resonance imaging at 3 Tesla (non-compatible implants, metallic foreign bodies, insulin pump, pacemaker).

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Northwestern University,

Ivan Alekseichuk, PhD, PRINCIPAL_INVESTIGATOR, Northwestern University

Study Record Dates

2026-08-31