RECRUITING

Low Level Light Therapy & Skin Pigmentation

Conditions

Dry Eye Meibomian Gland Dysfunction (Disorder)Meibomian Gland LLLT Low-level light therapy

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to determine if there is a difference in eyelid temperature after low-level light therapy (LLLT) in individuals with different amounts of skin pigmentation and dry eye/meibomian gland disease. Participants will have 3 fifteen minute in office LLLT therapy sessions over a period of approximately 7 to 14 days.

Official Title

Low Level Light Therapy & Skin Pigmentation

Quick Facts

Study Start:2025-06-11

Study Completion:2026-08

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT07173530

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Ability to read and understand the study informed consent in English * Age 18 years or older at enrollment * Individuals with MGD based on one or more of the following clinical signs/symptoms, e.g., meibum quality score of 1-3 (Bron et al.), meibography score of 1, 2, or 3 on the Pult Meiboscale, non-invasive 1st tear break up time of 10 seconds or less, or an Ocular Surface Disease Index (OSDI) score greater than 12 points.	* Active anterior segment pathology (e.g., bacterial conjunctivitis, microbial keratitis) * History of systemic disease associated with aqueous-deficient dry eye disease (e.g., Sjogren's syndrome) * History of corneal surgery, refractive surgery, or eyelid surgery within 6 months * History of corneal ectasia (e.g. keratoconus, Pellucid marginal degeneration) * History of ocular trauma within 6 months * History of LipiFlow, iLux, Meiboflow, IPL or LLLT within the last 12 months * Habitual use of photosensitizing medications within the last 30 days * Pregnant and/or lactating females, by self-report * Pigmented lesions, tattoos, or skin cancer in the periocular region * Unwilling to have eyes photographed or video recorded

Inclusion Criteria

Exclusion Criteria

* Ability to read and understand the study informed consent in English
* Age 18 years or older at enrollment
* Individuals with MGD based on one or more of the following clinical signs/symptoms, e.g., meibum quality score of 1-3 (Bron et al.), meibography score of 1, 2, or 3 on the Pult Meiboscale, non-invasive 1st tear break up time of 10 seconds or less, or an Ocular Surface Disease Index (OSDI) score greater than 12 points.

* Active anterior segment pathology (e.g., bacterial conjunctivitis, microbial keratitis)
* History of systemic disease associated with aqueous-deficient dry eye disease (e.g., Sjogren's syndrome)
* History of corneal surgery, refractive surgery, or eyelid surgery within 6 months
* History of corneal ectasia (e.g. keratoconus, Pellucid marginal degeneration)
* History of ocular trauma within 6 months
* History of LipiFlow, iLux, Meiboflow, IPL or LLLT within the last 12 months
* Habitual use of photosensitizing medications within the last 30 days
* Pregnant and/or lactating females, by self-report
* Pigmented lesions, tattoos, or skin cancer in the periocular region
* Unwilling to have eyes photographed or video recorded

Contacts and Locations

Study Contact

Eric Ritchey, OD, PhD

CONTACT

713-743-1933

erritche@central.uh.edu

Rachel Redfern, OD, PhD

CONTACT

713-743-1943

rredfern@uh.edu

Study Locations (Sites)

The University of Houston College of Optometry

Houston, Texas, 77204

United States

Collaborators and Investigators

Sponsor: University of Houston

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-06-11

Study Completion Date2026-08

Study Record Updates

Study Start Date2025-06-11

Study Completion Date2026-08

Terms related to this study

Keywords Provided by Researchers

Dry Eye
Meibomian Gland
LLLT
Low-level light therapy

Additional Relevant MeSH Terms

Dry Eye
Meibomian Gland Dysfunction (Disorder)