RECRUITING

IH, Brain Health, and T2D

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to use a randomized, placebo-controlled study design to rigorously examine the therapeutic potential of intermittent hypoxia (IH) for improving cerebrovascular health in older adults with and without type 2 diabetes mellitus (T2DM).

Official Title

Intermittent Hypoxia Training and Cerebrovascular Health in Older Adults With Type 2 Diabetes

Quick Facts

Study Start:2025-09-22

Study Completion:2028-06-30

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT07173543

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:60 Years to 85 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures. * Age is \> or = 60 and \< or = 85 years of age * Documented Type 2 diabetes * Scoring 26 or higher on the MoCA test	* diagnosis of type 2 diabetes \< 1 year prior to enrollment * HbA1c \<6.5% or \>10.0% * body mass index \> 40 kg/m 2 * incident cardiovascular events in the last year (heart attack, stroke) * symptomatic coronary artery disease and/or heart failure * uncontrolled hypertension * obstructive sleep apnea * pulmonary disease * dementia * renal impairment with creatinine clearance (eGFR) of \<60 ml/min * smoking or history of smoking within past one year

Inclusion Criteria

Exclusion Criteria

* Willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures.
* Age is \> or = 60 and \< or = 85 years of age
* Documented Type 2 diabetes
* Scoring 26 or higher on the MoCA test

* diagnosis of type 2 diabetes \< 1 year prior to enrollment
* HbA1c \<6.5% or \>10.0%
* body mass index \> 40 kg/m 2
* incident cardiovascular events in the last year (heart attack, stroke)
* symptomatic coronary artery disease and/or heart failure
* uncontrolled hypertension
* obstructive sleep apnea
* pulmonary disease
* dementia
* renal impairment with creatinine clearance (eGFR) of \<60 ml/min
* smoking or history of smoking within past one year

Contacts and Locations

Study Contact

Darren Casey, PHD

CONTACT

13193841009

darren-casey@uiowa.edu

Study Locations (Sites)

University of Iowa

Iowa City, Iowa, 52242

United States

Collaborators and Investigators

Sponsor: Darren P Casey

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-09-22

Study Completion Date2028-06-30

Study Record Updates

Study Start Date2025-09-22

Study Completion Date2028-06-30

Terms related to this study

Additional Relevant MeSH Terms

Type 2 Diabetes
Aging