RECRUITING

Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

By doing this research project, the investigators hope to learn which strategies work best to help veterans who are not benefiting from their first PTSD treatment or not completing between-session homework assignments regularly that might improve treatment response. The investigators also want to learn how best to match the right type and amount of treatment to each individual veteran. By conducting this research project, they hope to: * See if trying a different treatment strategy for veterans not responding to their first PTSD treatment would be more helpful * See if sending text message prompts between sessions encourages more completion of between-session homework

Official Title

Changing the Treatment Course: Clinical Trial of Sequenced Interventions to Optimize Treatment for Veterans With PTSD

Quick Facts

Study Start:2025-09-22
Study Completion:2028-08-14
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07176273

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Veterans eligible for PE and CPT at the participating PTSD treatment-providing clinic who are
  2. 2. At least 18 years or older
  3. 3. Score ≥ 31 on the PCL-5 secondary to a Criterion A traumatic event
  4. 4. Own a mobile device that can be used for the therapy companion mobile app (Prolonged Exposure (PE) coach or Cognitive Processing Therapy (CPT) coach).
  1. 1. Acute suicide risk requiring clinical intervention
  2. 2. Need for detoxification
  3. 3. Unmanaged psychosis or bipolar disorder
  4. 4. Severe cognitive impairment that makes it unlikely that participants can adhere to the study regimen (as evidenced by confusion, inability to track discussion or answer questions, or other clear and significant indicators of cognitive impairment)
  5. 5. Current or past 12-month engagement in PE or CPT.

Contacts and Locations

Study Contact

Stefanie LoSavio, PhD
CONTACT
210-562-6700
losavio@uthscsa.edu
Rebecca Sripada, PhD
CONTACT
734-222-7432
Rebecca.sripada@va.gov

Principal Investigator

Stefanie LoSavio, PhD
PRINCIPAL_INVESTIGATOR
The University of Texas Health Science Center at San Antonio
Rebecca Sripada, PhD
PRINCIPAL_INVESTIGATOR
VA Ann Arbor-506

Study Locations (Sites)

Augusta VA
Augusta, Georgia, 30904
United States
Ann Arbor VA
Ann Arbor, Michigan, 48105
United States
Battle Creek VA
Battle Creek, Michigan, 49037
United States
Salt Lake City VA
Salt Lake City, Utah, 84148
United States

Collaborators and Investigators

Sponsor: The University of Texas Health Science Center at San Antonio

  • Stefanie LoSavio, PhD, PRINCIPAL_INVESTIGATOR, The University of Texas Health Science Center at San Antonio
  • Rebecca Sripada, PhD, PRINCIPAL_INVESTIGATOR, VA Ann Arbor-506

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-09-22
Study Completion Date2028-08-14

Study Record Updates

Study Start Date2025-09-22
Study Completion Date2028-08-14

Terms related to this study

Keywords Provided by Researchers

  • Veterans

Additional Relevant MeSH Terms

  • Posttraumatic Stress Disorder
  • PTSD