RECRUITING

Determinants of Cardiorespiratory Fitness and Effects of HIIT in Patients With ANOCA Obstructive Coronary Artery Disease(ANOCA)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The main goal is to understand what causes reduced fitness in ANOCA and whether targeted exercise can help improve it. This study aims to better understand why patients with Angina and No Obstructive Coronary Artery Disease (ANOCA) have poor cardiorespiratory fitness and its effect on quality of life. Investigators also want to see if a structured high-intensity exercise program (HIIT), done with remote monitoring, can safely improve heart function, fitness, and quality of life in these patients. The Investigators will use a special exercise test called cardiopulmonary exercise testing to look for patterns that can help explain exercise limitations and quality of life in ANOCA before and after a remote high-intensity exercise program.

Official Title

Determinants of Cardiorespiratory Fitness and Effects of High Intensity Interval Training (HIIT) in Patients With Angina and No Obstructive Coronary Artery Disease (ANOCA)

Quick Facts

Study Start:2025-08-11
Study Completion:2026-04-14
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07182955

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 18-85
  2. * ANOCA (Anginal symptoms of chest pain or exertional dyspnea suspected to be from myocardial ischemia Invasive or CT coronary angiogram without obstructive epicardial CAD (≥50% left main or ≥70% other epicardial stenosis or fractional flow reserve ≤0.80)
  3. * Able to use the wearable and participate in a remote exercise program
  4. * Able to participate in intermittent high-intensity training.
  5. * Able to perform cardiopulmonary exercise testing (CPET)
  6. * Able to provide Health-related quality of life questionnaire (HRQOL)
  7. * Participants must be able to understand and provide informed consent in English and complete the study questionnaire in English
  1. * Systolic heart failure (LVEF \<50% or NYHA class III symptoms)
  2. * Prior myocardial infarction, coronary revascularization
  3. * Inability to safely undergo cardiopulmonary exercise testing, based on investigator's judgment
  4. * Pregnancy (due to unknown effects on CPET exercise markers)
  5. * Inability to provide informed consent
  6. * Life expectancy \<1 year
  7. * Prisoners
  8. * Cognitively impaired
  9. * Non-English speaking

Contacts and Locations

Study Contact

Rahel Askari
CONTACT
434-243-7195
rahel.askari@uvahealth.org

Principal Investigator

Jamieson M Bourque, MD, MHS
PRINCIPAL_INVESTIGATOR
University of Virginia

Study Locations (Sites)

University of Virginia Health System
Charlottesville, Virginia, 22908
United States

Collaborators and Investigators

Sponsor: University of Virginia

  • Jamieson M Bourque, MD, MHS, PRINCIPAL_INVESTIGATOR, University of Virginia

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-08-11
Study Completion Date2026-04-14

Study Record Updates

Study Start Date2025-08-11
Study Completion Date2026-04-14

Terms related to this study

Keywords Provided by Researchers

  • ANOCA/MINOCA
  • High Intensity Interval Training
  • CPET Phenotype
  • Cardiorespiratory Fitness

Additional Relevant MeSH Terms

  • MINOCA
  • Shortness of Breath
  • Atherosclerotic Heart Disease of Native Coronary Artery