RECRUITING

Quantitative Ultrasound(DeepUSFF) vs MRI-PDFF for Liver Fat Assessment in MASLD

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This multicenter prospective study aims to evaluate the correlation between quantitative ultrasound fat fraction (USFF) and MRI-PDFF (Proton Density Fat Fraction) for liver fat quantification in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). The study will compare the diagnostic accuracy of quantitative ultrasound imaging against MRI-PDFF as the reference standard.

Official Title

Evaluation of a Quantitative Ultrasound Model(DeepUSFF) for Liver Fat Quantification in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Multicenter Prospective Study Using MRI-PDFF as the Reference Standard

Quick Facts

Study Start:2025-06-24
Study Completion:2026-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07192159

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients with clinically suspected MASLD based on abnormal ultrasound or liver function tests requiring liver ultrasound or MRI examination
  2. * BMI ≥25 kg/m² or waist circumference \>90 cm (male) or \>80 cm (female), suggesting high likelihood of fatty liver disease
  3. * Living liver transplant donors requiring preoperative liver ultrasound or MRI examination
  4. * Age ≥18 years
  5. * Understanding and signing informed consent
  1. * Significant alcohol consumption in the past 2 years:
  2. * History of esophageal varices, ascites, hepatic encephalopathy, or acute biliary obstruction
  3. * History of liver cancer diagnosis or treatment
  4. * History of liver surgery
  5. * Pregnancy
  6. * Inability to obtain adequate liver ultrasound imaging:

Contacts and Locations

Study Contact

Jeong Min Lee, MD
CONTACT
+82-2-2072-3154
jmsh@snu.ac.kr
Eun Jung Choi, RN
CONTACT
+82-2-2072-4177
eunjung0213@snu.ac.kr

Principal Investigator

Jeong Min Lee, MD
PRINCIPAL_INVESTIGATOR
Seoul National University Hospital
Richard Gary Barr, MD
STUDY_DIRECTOR
Northeastern Ohio Radiology Research and Education Fund

Study Locations (Sites)

southwoods imaging (Northeastern Ohio Radiology Research and Education Fund )
Boardman, Ohio, 44512
United States

Collaborators and Investigators

Sponsor: Seoul National University Hospital

  • Jeong Min Lee, MD, PRINCIPAL_INVESTIGATOR, Seoul National University Hospital
  • Richard Gary Barr, MD, STUDY_DIRECTOR, Northeastern Ohio Radiology Research and Education Fund

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-06-24
Study Completion Date2026-06-30

Study Record Updates

Study Start Date2025-06-24
Study Completion Date2026-06-30

Terms related to this study

Keywords Provided by Researchers

  • Metabolic dysfunction-associated steatotic liver disease
  • Quantitative ultrasound
  • MRI-PDFF
  • Liver fat quantification
  • Hepatic steatosis
  • Deep learning

Additional Relevant MeSH Terms

  • Metabolic Dysfunction-Associated Steatotic Liver Disease
  • Hepatic Steatosis
  • Liver Disease Parenchymal