The purpose of this study is to determine the natural history of the hereditary forms of nephrolithiasis and chronic kidney disease (CKD), primary hyperoxaluria (PH), cystinuria, Dent disease and adenine phosphoribosyltransferase deficiency (APRTd) and acquired enteric hyperoxaluria (EH). The investigator will measure blood and urinary markers of inflammation and determine relationship to the disease course. Cross-comparisons among the disorders will allow us to better evaluate mechanisms of renal dysfunction in these disorders.
The purpose of this study is to determine the natural history of the hereditary forms of nephrolithiasis and chronic kidney disease (CKD), primary hyperoxaluria (PH), cystinuria, Dent disease and adenine phosphoribosyltransferase deficiency (APRTd) and acquired enteric hyperoxaluria (EH). The investigator will measure blood and urinary markers of inflammation and determine relationship to the disease course. Cross-comparisons among the disorders will allow us to better evaluate mechanisms of renal dysfunction in these disorders.
Prospective Research Rare Kidney Stones (ProRKS)
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University of Alabama @ Birmingham, Birmingham, Alabama, United States, 35294
Mayo Clinic Jacksonville, Jacksonville, Florida, United States, 32224
Children's Memorial Hospital, Chicago, Illinois, United States, 60614
Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States, 02115
Mayo Clinic Hyperoxaluria Center, Rochester, Minnesota, United States, 55905
New York University, New York, New York, United States, 10010
Cincinnati Children's Hosptial Medical Center, Cincinnati, Ohio, United States, 45229
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States, 19104
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
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ALL
No
Mayo Clinic,
John Lieske, MD, PRINCIPAL_INVESTIGATOR, Mayo Clinic
2026-07