Clinical Applications of Advanced Ophthalmic Imaging

Description

The purpose of this study is to determine the clinical application of advanced ophthalmic imaging devices such as optical coherence tomography (OCT), retinal function imager (RFI), slit-lamp biomicroscopy (SLB), PERG in diseased eyes and normal controls. There are two phases in this study. The first phase is an observational phase which studies the eye in various conditions. The second phase is an interventional phase which studies the changes in the eyes after taking an over-the-counter medical food (Ocufolin) for 6 months.

Conditions

Multiple Sclerosis, Dry Eye Syndromes, Diabetic Retinopathy, Presbyopia, Myopia, Dementia

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Study Overview

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Study Details

Study overview

The purpose of this study is to determine the clinical application of advanced ophthalmic imaging devices such as optical coherence tomography (OCT), retinal function imager (RFI), slit-lamp biomicroscopy (SLB), PERG in diseased eyes and normal controls. There are two phases in this study. The first phase is an observational phase which studies the eye in various conditions. The second phase is an interventional phase which studies the changes in the eyes after taking an over-the-counter medical food (Ocufolin) for 6 months.

Clinical Applications of Advanced Ophthalmic Imaging

Clinical Applications of Advanced Ophthalmic Imaging

Condition
Multiple Sclerosis
Intervention / Treatment

-

Contacts and Locations

Miami

Bascom Palmer Eye Institute, Miami, Florida, United States, 33136

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Self-reported normal healthy subjects;
  • 2. Clinical diagnosis of Alzheimer's Disease, mild cognitive impairment, multiple sclerosis, dry eye, myopia, diabetics and stroke;
  • 3. Who can keep the eye open for imaging.
  • 1. who can not read and sign the ICF;
  • 2. who can not receiving ophthalmic imaging;
  • 3. who cannot tolerate bright light during imaging.
  • 1. Is at least 18 years old and has full legal capacity to volunteer;
  • 2. Has read and signed the IRB Informed Consent Document;
  • 3. Is willing and able to follow participant instructions;
  • 4. Has clear corneas and crystalline lens;
  • 5. Initial visual acuities were 20/80 or better;
  • 6. MTHFR C677TT homozygous, or MTHFR C677T/A1298C compound heterozygous with mild to moderate micro-aneurismal vascular retinopathy disease;
  • 7. Hemoglobin A1c is 10 or less;
  • 8. Normotensive with or without medications;
  • 9. Without retinal capillary dropout or macular edema;
  • 10. Blood homocysteine \> 9.
  • 1. Has an active ocular disease;
  • 2. Has had surgery or an eye injury within 6 months.

Ages Eligible for Study

18 Years to 99 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Miami,

Jianhua Wang, MD, PhD, PRINCIPAL_INVESTIGATOR, Bascom Palmer Eye Institute, University of Miami, Miami, FL

Study Record Dates

2026-12-31