RECRUITING

Clinical Applications of Advanced Ophthalmic Imaging

Conditions

Multiple Sclerosis Dry Eye Syndromes Diabetic Retinopathy Presbyopia Myopia Dementia

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to determine the clinical application of advanced ophthalmic imaging devices such as optical coherence tomography (OCT), retinal function imager (RFI), slit-lamp biomicroscopy (SLB), PERG in diseased eyes and normal controls. There are two phases in this study. The first phase is an observational phase which studies the eye in various conditions. The second phase is an interventional phase which studies the changes in the eyes after taking an over-the-counter medical food (Ocufolin) for 6 months.

Official Title

Clinical Applications of Advanced Ophthalmic Imaging

Quick Facts

Study Start:2007-01-01

Study Completion:2026-12-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT03135327

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 99 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
1. Self-reported normal healthy subjects; 2. Clinical diagnosis of Alzheimer's Disease, mild cognitive impairment, multiple sclerosis, dry eye, myopia, diabetics and stroke; 3. Who can keep the eye open for imaging.	1. who can not read and sign the ICF; 2. who can not receiving ophthalmic imaging; 3. who cannot tolerate bright light during imaging. 1. Is at least 18 years old and has full legal capacity to volunteer; 2. Has read and signed the IRB Informed Consent Document; 3. Is willing and able to follow participant instructions; 4. Has clear corneas and crystalline lens; 5. Initial visual acuities were 20/80 or better; 6. MTHFR C677TT homozygous, or MTHFR C677T/A1298C compound heterozygous with mild to moderate micro-aneurismal vascular retinopathy disease; 7. Hemoglobin A1c is 10 or less; 8. Normotensive with or without medications; 9. Without retinal capillary dropout or macular edema; 10. Blood homocysteine \> 9. 1. Has an active ocular disease; 2. Has had surgery or an eye injury within 6 months.

Inclusion Criteria

Exclusion Criteria

1. Self-reported normal healthy subjects;
2. Clinical diagnosis of Alzheimer's Disease, mild cognitive impairment, multiple sclerosis, dry eye, myopia, diabetics and stroke;
3. Who can keep the eye open for imaging.

1. who can not read and sign the ICF;
2. who can not receiving ophthalmic imaging;
3. who cannot tolerate bright light during imaging.
1. Is at least 18 years old and has full legal capacity to volunteer;
2. Has read and signed the IRB Informed Consent Document;
3. Is willing and able to follow participant instructions;
4. Has clear corneas and crystalline lens;
5. Initial visual acuities were 20/80 or better;
6. MTHFR C677TT homozygous, or MTHFR C677T/A1298C compound heterozygous with mild to moderate micro-aneurismal vascular retinopathy disease;
7. Hemoglobin A1c is 10 or less;
8. Normotensive with or without medications;
9. Without retinal capillary dropout or macular edema;
10. Blood homocysteine \> 9.
1. Has an active ocular disease;
2. Has had surgery or an eye injury within 6 months.

Contacts and Locations

Study Contact

Jianhua Wang, MD, PhD

CONTACT

3054825010

jwang3@med.miami.edu

Principal Investigator

Jianhua Wang, MD, PhD

PRINCIPAL_INVESTIGATOR

Bascom Palmer Eye Institute, University of Miami, Miami, FL

Study Locations (Sites)

Bascom Palmer Eye Institute

Miami, Florida, 33136

United States

Collaborators and Investigators

Sponsor: University of Miami

Jianhua Wang, MD, PhD, PRINCIPAL_INVESTIGATOR, Bascom Palmer Eye Institute, University of Miami, Miami, FL

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2007-01-01

Study Completion Date2026-12-31

Study Record Updates

Study Start Date2007-01-01

Study Completion Date2026-12-31

Terms related to this study

Additional Relevant MeSH Terms

Multiple Sclerosis
Dry Eye Syndromes
Diabetic Retinopathy
Presbyopia
Myopia
Dementia