Cabozantinib in Patients With Metastatic Castrate Resistant Prostate Cancer (mCRPC)

Description

The purpose of this study is to determine what effects (good and bad) cabozantinib has in treatment of patients with metastatic castrate resistant prostate cancer (mCRPC). The hypothesis for this trial is that cabozantinib has anti-tumor activity in a molecularly-selected group of patients with CRPC or patients with liver metastases.

Conditions

Prostate Cancer

Study Overview

Study Details

Study overview

The purpose of this study is to determine what effects (good and bad) cabozantinib has in treatment of patients with metastatic castrate resistant prostate cancer (mCRPC). The hypothesis for this trial is that cabozantinib has anti-tumor activity in a molecularly-selected group of patients with CRPC or patients with liver metastases.

Open Label Phase II Trial of Cabozantinib in Patients With Metastatic Castrate Resistant Prostate Cancer (mCRPC) and Known Amplifications or Activating Mutations in Gene Targets of Cabozantinib or Liver Metastases Who Have Received Prior Anti-Androgen Therapy

Cabozantinib in Patients With Metastatic Castrate Resistant Prostate Cancer (mCRPC)

Condition
Prostate Cancer
Intervention / Treatment

-

Contacts and Locations

Detroit

Karmanos Cancer Institute, Detroit, Michigan, United States, 48201

New York

Columbia University Irving Medical Center, New York, New York, United States, 10032

New York

Weill Cornell Medicine, New York, New York, United States, 10065

Pittsburgh

University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania, United States, 15232

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    18 Years to 99 Years

    Sexes Eligible for Study

    MALE

    Accepts Healthy Volunteers

    No

    Collaborators and Investigators

    Weill Medical College of Cornell University,

    David M Nanus, MD, PRINCIPAL_INVESTIGATOR, Weill Medical College of Cornell University

    Study Record Dates

    2027-07