The Impact of Overnight Nutrition Support on Sleep and Circadian Rhythm Disruption in the ICU

Description

The purpose of this study is to determine whether modifying the timing of nutrition support from overnight to daytime enhances sleep quality, preserves circadian rhythms, and improves overall inflammation and cardiometabolic profiles in postoperative patients in the cardiac surgical ICU on enteral nutrition.

Conditions

Feeding Patterns, Sleep, Glucose Intolerance

Talk to us

Study Overview

On this page

Study Details

Study overview

The purpose of this study is to determine whether modifying the timing of nutrition support from overnight to daytime enhances sleep quality, preserves circadian rhythms, and improves overall inflammation and cardiometabolic profiles in postoperative patients in the cardiac surgical ICU on enteral nutrition.

The Impact of Overnight Nutrition Support on Sleep and Circadian Rhythm Disruption in the ICU

The Impact of Overnight Nutrition Support on Sleep and Circadian Rhythm Disruption in the ICU

Condition
Feeding Patterns
Intervention / Treatment

-

Contacts and Locations

Boston

Massachusetts General Hospital, Boston, Massachusetts, United States, 02114

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adult male or non-pregnant female volunteers (age 18+)
  • * Scheduled for a cardiac surgical procedure with planned post-operative admission to the ICU for \>48 hours
  • * Able and willing to give consent and comply with study procedures
  • * Blind, deaf or unable to speak English
  • * Women who are pregnant or nursing
  • * Contraindications to safe use enteral nutrition, including gastrointestinal obstruction
  • * Personal history of intestinal malabsorption, gallbladder disease or pancreatitis
  • * Dietary restrictions precluding enteral feeds
  • * Renal and liver failure requiring dialysis or Child-Pugh score \> 7
  • * Chronic therapy with benzodiazepines and/or antipsychotics
  • * Severe deficit due to structural or anoxic brain damage
  • * With skin condition that precludes wearing sensors

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Massachusetts General Hospital,

Hassan S Dashti, Ph.D., R.D., PRINCIPAL_INVESTIGATOR, Massachusetts General Hospital

Study Record Dates

2025-12-31