Baseline Atrial Fibrosis Predicts Risk for Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

Description

The study aims to evaluate and compare the incidence of atrial arrhythmias (including Post-Operative Atrial Fibrillation (POAF), atrial flutter, and atrial tachycardia) stratified by baseline Utah fibrosis stages and overall fibrosis (%) of the left atrial wall area. The investigators hypothesize that patients with a higher baseline Utah fibrosis staging will experience a higher incidence of POAF. The study also aims to evaluate and compare the in-hospital mortality, length-of-stay (LOS), complication rates (strokes, pneumonia, respiratory failure etc.) of the different Utah fibrosis stage cohorts. Perform cost analysis and compare between patients with POAF and patients without POAF. The investigators hypothesize that patients experiencing POAF will have a higher mortality rate, longer LOS, greater complications, and therefore, additional hospital costs.

Conditions

Atrial Fibrillation, Atrial Arrhythmia, Atrial Flutter, Atrial Tachycardia

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Study Overview

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Study Details

Study overview

The study aims to evaluate and compare the incidence of atrial arrhythmias (including Post-Operative Atrial Fibrillation (POAF), atrial flutter, and atrial tachycardia) stratified by baseline Utah fibrosis stages and overall fibrosis (%) of the left atrial wall area. The investigators hypothesize that patients with a higher baseline Utah fibrosis staging will experience a higher incidence of POAF. The study also aims to evaluate and compare the in-hospital mortality, length-of-stay (LOS), complication rates (strokes, pneumonia, respiratory failure etc.) of the different Utah fibrosis stage cohorts. Perform cost analysis and compare between patients with POAF and patients without POAF. The investigators hypothesize that patients experiencing POAF will have a higher mortality rate, longer LOS, greater complications, and therefore, additional hospital costs.

Baseline Atrial Fibrosis Predicts Risk for Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery: A Pilot Study for SAPPORO-AF

Baseline Atrial Fibrosis Predicts Risk for Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

Condition
Atrial Fibrillation
Intervention / Treatment

-

Contacts and Locations

New Orleans

Tulane University Medical Center, New Orleans, Louisiana, United States, 70112

New Orleans

University Medical Center New Orleans, New Orleans, Louisiana, United States, 70112

Saint Louis

Washington University Barnes-Jewish Hospital, Saint Louis, Missouri, United States, 63110

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Male or female patients age 40 years of age or older
  • * Patients with no history of atrial arrhythmia (atrial fibrillation, atrial flutter, atrial tachycardia) scheduled to undergo cardiac surgery (These surgeries include but are not limited to coronary artery bypass graft (CABG), valvular repair/reconstruction, aneurysm repair, and insertion of pacemaker).
  • * Patients with a history of atrial arrhythmia (atrial fibrillation, atrial flutter, atrial tachycardia)
  • * Patients with a history of cardiac or open chest surgery
  • * Patients with a history of catheter ablation
  • * Patients under the age of 40
  • * Patients with left ventricular assist device (LVAD) or scheduled to have LVAD implanted
  • * Patients who have previously undergone extracorporeal membrane oxygenation (ECMO)
  • * Patients who have undergone or will undergo heart transplantation
  • * Patients with any health related Late Gadolinium Enhancement (LGE)-MRI contraindications (including previous allergic reaction to gadolinium, pacemakers, defibrillators, other devices/implants contraindicated for MRI)
  • * Acute or chronic severe renal disease with a low glomerular filtration rate (GFR), \<30 mL per minute per 1.73 m2 will be excluded from the trial. (A creatinine measurement should be available within the last 6 months. If not, a creatinine blood test will be drawn to assess for renal function before the MRI acquisition).
  • * Patients weighing \> 300 lbs. (MRI image quality decreases due to increased body mass index)
  • * Patients currently pregnant or breastfeeding, or plan to become pregnant during the study period
  • * Patients with cognitive impairment preventing them from giving informed consent will be excluded from the study
  • * Patients who cannot read, speak, and/or understand English

Ages Eligible for Study

40 Years to 120 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Tulane University,

Nassir Marrouche, MD, PRINCIPAL_INVESTIGATOR, Tulane University

Study Record Dates

2024-07-25