RECRUITING

Chronic Pain in Rheumatoid Arthritis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The objective is to identify modifiable clinical factors and neurobiological pathways that lead to the development of chronic pain in patients with early rheumatoid arthritis. Participants will undergo quantitative sensory testing, a type of testing that involves assessing response to well-defined, quantifiable painful stimuli, at 0, 3, and 12 months. A subset of participants will also undergo magnetic resonance imaging at 0 and 12 months to assess neuroimaging markers that have previously been shown to be involved in chronic pain.

Official Title

CNS Pain Mechanisms in Early Rheumatoid Arthritis: Implications for the Acute to Chronic Pain Transition

Quick Facts

Study Start:2021-10-12
Study Completion:2026-04-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05038553

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Kathleen Aren, MPH
CONTACT
312-503-1824
kathleen.aren@northwestern.edu
Mary Carns, MS
CONTACT
312-503-1137
m-carns@northwestern.edu

Principal Investigator

Yvonne C Lee, MD, MMSc
PRINCIPAL_INVESTIGATOR
Northwestern University

Study Locations (Sites)

University of Colorado
Denver, Colorado, 80045
United States
Northwestern University
Chicago, Illinois, 60611
United States
Johns Hopkins University
Baltimore, Maryland, 21224
United States
University of Michigan
Ann Arbor, Michigan, 48019
United States
Hospital for Special Surgery
New York, New York, 10021
United States

Collaborators and Investigators

Sponsor: Northwestern University

  • Yvonne C Lee, MD, MMSc, PRINCIPAL_INVESTIGATOR, Northwestern University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-10-12
Study Completion Date2026-04-12

Study Record Updates

Study Start Date2021-10-12
Study Completion Date2026-04-12

Terms related to this study

Additional Relevant MeSH Terms

  • Arthritis, Rheumatoid
  • Pain