Clinical Trial of Approaches to Prostate Cancer Surgery

Description

This is a prospective, randomized controlled trial to compare cancer control and health-related quality of life following pelvic fascia-sparing radical prostatectomy versus standard radical prostatectomy. The investigators hypothesize that pelvic fascia-sparing radical prostatectomy will have similar cancer control (primary outcome) and sexual function outcomes; and significantly better urinary function, penile shortening/deformity and inguinal hernia risks as compared to radical prostatectomy.

Conditions

Prostate Cancer

Study Overview

Study Details

Study overview

This is a prospective, randomized controlled trial to compare cancer control and health-related quality of life following pelvic fascia-sparing radical prostatectomy versus standard radical prostatectomy. The investigators hypothesize that pelvic fascia-sparing radical prostatectomy will have similar cancer control (primary outcome) and sexual function outcomes; and significantly better urinary function, penile shortening/deformity and inguinal hernia risks as compared to radical prostatectomy.

Clinical TrIAL of Approaches to Prostate cAncer suRgery

Clinical Trial of Approaches to Prostate Cancer Surgery

Condition
Prostate Cancer
Intervention / Treatment

-

Contacts and Locations

Washington

Georgetown University, Washington, District of Columbia, United States, 20007

Chicago

Northwestern University, Chicago, Illinois, United States, 60611

Baltimore

Johns Hopkins University, Baltimore, Maryland, United States, 21287

New York

Weill Cornell Medicine, New York, New York, United States, 10065

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Male sex
  • * Age ≥40 years or ≤80 years
  • * Scheduled for radical prostatectomy for clinically localized prostate cancer
  • * Able to read and speak English or Spanish
  • * Willingness to sign informed consent and adhere to the study protocol
  • * Prior major pelvic surgery or radiotherapy
  • * Suspicion of N1 disease (i.e., any lymph node greater than 1cm in maximal diameter)

Ages Eligible for Study

40 Years to 80 Years

Sexes Eligible for Study

MALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Weill Medical College of Cornell University,

Jim C Hu, MD, MPH, PRINCIPAL_INVESTIGATOR, Weill Medical College of Cornell University

Study Record Dates

2026-12