Evaluation of DNA Methylation Signatures for the Diagnosis and Management of Thyroid Nodules

Description

This clinical trial evaluates deoxyribonucleic acid (DNA) methylation signatures in diagnosing and managing thyroid nodules. The purpose of this research is to develop a new test for thyroid cancer. This test will use needle biopsies (small collections of tissue with a needle) from the thyroid to determine whether the participant has a malignant (cancer) or benign (not showing cancer) thyroid tumor. The information learned from this trial may help develop a more accurate test so that patients do not have unnecessary surgeries for nodules that are thought to be suspicious but are actually benign.

Conditions

Thyroid Gland Carcinoma

Study Overview

Study Details

Study overview

This clinical trial evaluates deoxyribonucleic acid (DNA) methylation signatures in diagnosing and managing thyroid nodules. The purpose of this research is to develop a new test for thyroid cancer. This test will use needle biopsies (small collections of tissue with a needle) from the thyroid to determine whether the participant has a malignant (cancer) or benign (not showing cancer) thyroid tumor. The information learned from this trial may help develop a more accurate test so that patients do not have unnecessary surgeries for nodules that are thought to be suspicious but are actually benign.

Evaluation of DNA Methylation Signatures in Diagnosis and Management of Thyroid Nodules

Evaluation of DNA Methylation Signatures for the Diagnosis and Management of Thyroid Nodules

Condition
Thyroid Gland Carcinoma
Intervention / Treatment

-

Contacts and Locations

Duarte

City of Hope Medical Center, Duarte, California, United States, 91010

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients without impaired decision-making capacity and who are undergoing needle biopsies for thyroid nodule diagnosis
  • * Over the age of 18
  • * Any gender, race and ethnicity
  • * Patients must provide informed consent prior to use of their tissues and clinical data
  • * Children are excluded from the study, since the biology of children thyroid nodules is different from adults

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

City of Hope Medical Center,

John H Yim, PRINCIPAL_INVESTIGATOR, City of Hope Medical Center

Study Record Dates

2026-10-22