Evaluation of Neurocognitive Changes in Parkinson's Disease After Low Frequency Burst Stimulation

Description

This study aims to determine whether direct brain stimulation of specific regions and ranges improves cognition in people with Parkinsons Disease (PD) who already have a deep brain stimulator implanted. Research activities consist of 32 subjects undergoing stimulation changes to their device and being administered neurocognitive tests to evaluate the changes. An fMRI scan will also be done at baseline and at weeks 15 and 27. All subjects will undergo the stimulation changes in a randomized double blind crossover study. Evaluation of stimulation changes will be assessed through analysis of neurocognitive data.

Conditions

Parkinson Disease

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Study Overview

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Study Details

Study overview

This study aims to determine whether direct brain stimulation of specific regions and ranges improves cognition in people with Parkinsons Disease (PD) who already have a deep brain stimulator implanted. Research activities consist of 32 subjects undergoing stimulation changes to their device and being administered neurocognitive tests to evaluate the changes. An fMRI scan will also be done at baseline and at weeks 15 and 27. All subjects will undergo the stimulation changes in a randomized double blind crossover study. Evaluation of stimulation changes will be assessed through analysis of neurocognitive data.

Theta Burst Subthalamic Nucleus Deep Brain Stimulation for Cognitive and Motor Improvements in Parkinson's Disease

Evaluation of Neurocognitive Changes in Parkinson's Disease After Low Frequency Burst Stimulation

Condition
Parkinson Disease
Intervention / Treatment

-

Contacts and Locations

Los Angeles

University of Southern California Keck School of Medicine, Los Angeles, California, United States, 90033

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Male or female patients who had previously undergone bilateral STN deep brain stimulation implantation
  • 2. Age \>18 years old
  • 3. Stable medication regimen for at least 3 months.
  • 4. Patient informed and able to give written consent
  • 5. Able to comply with all testing, follow-ups and study appointments and protocols
  • 1. History of epilepsy or seizure
  • 2. History of dementia
  • 3. History of major substance abuse

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Southern California,

Darrin Lee, MD PhD, PRINCIPAL_INVESTIGATOR, University of Southern California, Keck School of Medicine

Study Record Dates

2026-06-11