RECRUITING

Evaluation of Neurocognitive Changes in Parkinson's Disease After Low Frequency Burst Stimulation

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study aims to determine whether direct brain stimulation of specific regions and ranges improves cognition in people with Parkinsons Disease (PD) who already have a deep brain stimulator implanted. Research activities consist of 32 subjects undergoing stimulation changes to their device and being administered neurocognitive tests to evaluate the changes. An fMRI scan will also be done at baseline and at weeks 15 and 27. All subjects will undergo the stimulation changes in a randomized double blind crossover study. Evaluation of stimulation changes will be assessed through analysis of neurocognitive data.

Official Title

Theta Burst Subthalamic Nucleus Deep Brain Stimulation for Cognitive and Motor Improvements in Parkinson's Disease

Quick Facts

Study Start:2022-01-11
Study Completion:2026-06-11
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05307055

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Male or female patients who had previously undergone bilateral STN deep brain stimulation implantation
  2. 2. Age \>18 years old
  3. 3. Stable medication regimen for at least 3 months.
  4. 4. Patient informed and able to give written consent
  5. 5. Able to comply with all testing, follow-ups and study appointments and protocols
  1. 1. History of epilepsy or seizure
  2. 2. History of dementia
  3. 3. History of major substance abuse

Contacts and Locations

Study Contact

Darrin Lee, MD PhD
CONTACT
9495220866
darrin.lee@med.usc.edu
Wooseong Choi, BS
CONTACT
8474017335
wooseong@usc.edu

Principal Investigator

Darrin Lee, MD PhD
PRINCIPAL_INVESTIGATOR
University of Southern California, Keck School of Medicine

Study Locations (Sites)

University of Southern California Keck School of Medicine
Los Angeles, California, 90033
United States

Collaborators and Investigators

Sponsor: University of Southern California

  • Darrin Lee, MD PhD, PRINCIPAL_INVESTIGATOR, University of Southern California, Keck School of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-01-11
Study Completion Date2026-06-11

Study Record Updates

Study Start Date2022-01-11
Study Completion Date2026-06-11

Terms related to this study

Keywords Provided by Researchers

  • Deep Brain Stimulation

Additional Relevant MeSH Terms

  • Parkinson Disease