Non-Nutritive Sweetener Consumption and Glucose Homeostasis in Older Adults With Prediabetes

Description

Animal and observational research in humans suggest that specific types of non-nutritive sweeteners (NNS) may impair glycemic control. However, whether NNS consumption impacts glucose homeostasis in middle-aged/older adults with prediabetes is unknown, and potential mechanisms by which this could occur have yet to be identified. The overall objective of this R21 proposal is to establish proof-of-concept for alterations in glucose homeostasis following intake of sucralose, but not aspartame, in middle-aged/older adults with prediabetes compared to a eucaloric diet with no NNS.

Conditions

Continuous Glucose Monitoring, Oral Glucose Tolerance, Insulin Sensitivity, Inflammatory Markers

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Study Overview

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Study Details

Study overview

Animal and observational research in humans suggest that specific types of non-nutritive sweeteners (NNS) may impair glycemic control. However, whether NNS consumption impacts glucose homeostasis in middle-aged/older adults with prediabetes is unknown, and potential mechanisms by which this could occur have yet to be identified. The overall objective of this R21 proposal is to establish proof-of-concept for alterations in glucose homeostasis following intake of sucralose, but not aspartame, in middle-aged/older adults with prediabetes compared to a eucaloric diet with no NNS.

Non-Nutritive Sweetener Consumption (Aspartame and Sucralose) and Glucose Homeostasis in Older Adults With Prediabetes

Non-Nutritive Sweetener Consumption and Glucose Homeostasis in Older Adults With Prediabetes

Condition
Continuous Glucose Monitoring
Intervention / Treatment

-

Contacts and Locations

Blacksburg

Virginia Tech, Blacksburg, Virginia, United States, 24061

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 50+ years
  • * Prediabetic (fasting glucose concentration of 100-125 mg/dL, 2-hour oral glucose tolerance test glucose concentration of 140-199 mg/dL, or a HbA1c value of 5.7% to 6.4%)
  • * Weight stable for previous 6 months (±2 kg)
  • * BMI \<40 kg/m2
  • * Sedentary to recreationally active
  • * No plans to gain/lose weight or change physical activity level
  • * Willing to pick up food daily and consume foods provided for an 8-week period
  • * Verbal and written informed consent
  • * Approval by Medical Director
  • * Consume less than one serving of non-nutritive sweetener per week
  • * BMI \>40 kg/m2
  • * Diabetes or diabetes medication
  • * Antibiotic, prebiotic or prebiotic use in prior 3 months
  • * Uncontrolled hypertension (blood pressure (BP) \> 159/99 mmHg)
  • * Diagnosed inflammatory bowel disease
  • * Past or current heart diseases, stroke, respiratory disease, endocrine or metabolic disease, or hematological-oncological disease
  • * Vegetarian or vegan
  • * Pregnant or plans to become pregnant
  • * Breastfeeding
  • * Food allergies or aversions, Phenylketonuria (PKU)
  • * Estrogen or testosterone usage

Ages Eligible for Study

50 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Virginia Polytechnic Institute and State University,

Valisa Hedrick, PhD, PRINCIPAL_INVESTIGATOR, Virginia Polytechnic Institute and State University

Study Record Dates

2025-02-28