Inhaled Isopropyl Alcohol for Treatment of Nausea

Description

To determine the efficacy of inhaled isopropyl alcohol in treating nausea/vomiting among pediatric patients compared with the conventional ondansetron, or placebo treatment in a tertiary care pediatric emergency department.

Conditions

Vomiting, Nausea, Children, Only

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Study Overview

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Study Details

Study overview

To determine the efficacy of inhaled isopropyl alcohol in treating nausea/vomiting among pediatric patients compared with the conventional ondansetron, or placebo treatment in a tertiary care pediatric emergency department.

Inhaled Isopropyl Alcohol for the Treatment of Nausea in a Pediatric Emergency Department: A Open Label, Randomized Controlled Clinical Trial

Inhaled Isopropyl Alcohol for Treatment of Nausea

Condition
Vomiting
Intervention / Treatment

-

Contacts and Locations

Buffalo

Oishei Children's Hospital, Buffalo, New York, United States, 14203

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients with a chief complaint of nausea or vomiting
  • * Ages 7-178 years, both sexes
  • * Weight ≥ 15 kg
  • * Baxter Animated Retching Faces (BARF) nausea severity score ≥ 4/10
  • * 1. Require IV access
  • * Inability to breathe in/out through the nose
  • * Anosmia (self- or parental report)
  • * Allergy to isopropyl alcohol or ondansetron
  • * Current or history of alcohol abuse
  • * Inability to communicate feeling nauseous
  • * Inability to follow directions regarding taking deep breaths through the nose
  • * Known prolonged QT interval
  • * Pregnancy
  • * Received antiemetics within the last 8 hours
  • * Currently taking apomorphine

Ages Eligible for Study

7 Years to 17 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

State University of New York at Buffalo,

Alana Koehler, MD, PRINCIPAL_INVESTIGATOR, SUNY Buffalo

Heather Territo, MD, STUDY_DIRECTOR, SUNY Buffalo

Study Record Dates

2025-06-30