RECRUITING

Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of the second part of the study is to examine the effect of reflex training in the leg to decrease neuropathic pain. For this, the researchers are recruiting 15 individuals with neuropathic pain due to spinal cord injury to participate in the reflex training procedure. The study involves approximately 50 visits with a total study duration of about 6.5 months (3 months for baseline and training phases followed by 1 month and 3 month follow-up visits).

Official Title

Targeted Spinal Cord Plasticity for Alleviating SCI-related Neuropathic Pain

Quick Facts

Study Start:2023-03-27
Study Completion:2026-10-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05492188

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. neurologically stable (\>1 year post SCI)
  2. 2. medical clearance to participate
  3. 3. ability to stand with or without an assistive device for at least 3 minutes at a time
  4. 4. expectation that current medication will be maintained without change for at least 3 months (stable use of anti-spasticity medication is accepted)
  5. 5. For participants with neuropathic pain, the area of neuropathic pain must include lower leg.
  1. 1. motoneuron injury
  2. 2. known cardiac condition
  3. 3. medically unstable condition (incl. pregnancy)
  4. 4. cognitive impairment
  5. 5. uncontrolled peripheral neuropathy
  6. 6. frequent use of electrical spinal stimulation (either transcutaneous or epidural) for pain treatment
  7. 7. daily use of electrical stimulation to the leg
  8. 8. complete lack of cutaneous sensation around foot.

Contacts and Locations

Study Contact

Blair Dellenbach, MSOT
CONTACT
843-792-6313
stecb@musc.edu

Principal Investigator

Aiko Thompson, PhD
PRINCIPAL_INVESTIGATOR
Medical University of South Carolina

Study Locations (Sites)

Medical University of South Carolina
Charleston, South Carolina, 29425
United States

Collaborators and Investigators

Sponsor: Medical University of South Carolina

  • Aiko Thompson, PhD, PRINCIPAL_INVESTIGATOR, Medical University of South Carolina

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-03-27
Study Completion Date2026-10-01

Study Record Updates

Study Start Date2023-03-27
Study Completion Date2026-10-01

Terms related to this study

Keywords Provided by Researchers

  • Neuroplasticity

Additional Relevant MeSH Terms

  • Spinal Cord Injuries
  • Neuropathic Pain
  • Neurological Injury
  • Pain