A Study on the Effects of Exercise Therapy on Signs of Prostate Cancer

Description

The purpose of this study is to find out the effects of exercise therapy on indicators of prostate cancer in people with low-risk prostate cancer who are on active surveillance. The exercise therapy in this study will be regular home-based walking sessions on a treadmill, and that therapy will be assigned by an exercise physiologist (a medical professional who studies how exercise affects the human body). Some participants in this study will have the assigned exercise therapy, and some participants will participate in their usual exercise routines. Researchers will compare how the assigned exercise therapy and the usual exercise routines affect indicators of prostate cancer in participants. This study will not provide treatment for prostate cancer.

Conditions

Prostate Cancer, Prostate Adenocarcinoma, Localized Prostate Carcinoma

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Study Overview

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Study Details

Study overview

The purpose of this study is to find out the effects of exercise therapy on indicators of prostate cancer in people with low-risk prostate cancer who are on active surveillance. The exercise therapy in this study will be regular home-based walking sessions on a treadmill, and that therapy will be assigned by an exercise physiologist (a medical professional who studies how exercise affects the human body). Some participants in this study will have the assigned exercise therapy, and some participants will participate in their usual exercise routines. Researchers will compare how the assigned exercise therapy and the usual exercise routines affect indicators of prostate cancer in participants. This study will not provide treatment for prostate cancer.

Phase 2 Trial of Exercise Therapy on Markers of Progression in Localized Prostate Cancer

A Study on the Effects of Exercise Therapy on Signs of Prostate Cancer

Condition
Prostate Cancer
Intervention / Treatment

-

Contacts and Locations

Los Angeles

University of California, Los Angeles (Data and Specimen Analysis Only), Los Angeles, California, United States, 90095-1781

Hartford

Hartford Healthcare Alliance (Data collection only), Hartford, Connecticut, United States, 06102

Basking Ridge

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey, United States, 07920

Middletown

Memorial Sloan Kettering Monmouth (Limited protocol activities), Middletown, New Jersey, United States, 07748

Montvale

Memorial Sloan Kettering Bergen (Limited protocol activities), Montvale, New Jersey, United States, 07645

Commack

Memorial Sloan Kettering Suffolk - Commack (Limited protocol activities), Commack, New York, United States, 11725

Harrison

Memorial Sloan Kettering Westchester (Limited protocol activities), Harrison, New York, United States, 10604

New York

Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York, New York, United States, 10065

Rockville Centre

Memorial Sloan Kettering Nassau (Limited protocol activites), Rockville Centre, New York, United States, 11553

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age ≥ 18
  • * Men with histologically confirmed localized prostate cancer undergoing active surveillance.
  • * Inactive, defined as not meeting the national exercise guidelines for cancer patients (\<150 minutes/week of moderate or vigorous exercise)43 as assessed by remote activity and heart rate tracking for a 7-day period prior to study entry (general physical activity screening assessment via smart watch).
  • * Screening clearance by an MSK Exercise Physiologist (i.e., review of ECG and PAR-Q)
  • * BMI \<40 kg/m\^2
  • * Enrollment in any other program that may alter the impact of exercise on tumor outcomes (e.g., weight loss program)
  • * Any neoadjuvant anticancer treatment of any kind for prostate cancer in the last 5 years
  • * Any history of systemic anticancer therapy in the last 15 years
  • * Distant metastatic malignancy of any kind
  • * Any other condition or intercurrent illness that, in the opinion of the investigator, makes the subject a poor candidate for study participation

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

MALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Memorial Sloan Kettering Cancer Center,

Lee Jones, PhD, PRINCIPAL_INVESTIGATOR, Memorial Sloan Kettering Cancer Center

Study Record Dates

2027-02-10