Analgesia-First Sedation in Trauma Patients

Description

The study's aim is to ascertain the best approach for providing sedation and pain management for patients who have sustained trauma and are requiring respiratory support from a mechanical ventilator. The common approach to patients who need mechanical ventilation is to provide continuous drips of sedatives and pain medicine and awaken the patient once a day to check the brain functions. Another approach is to provide pain medicine and reserve sedatives for only a short duration when needed. The difference between approaches has not been studied in Trauma patients.

Conditions

Mechanical Ventilation, Respiratory Failure

Study Overview

Study Details

Study overview

The study's aim is to ascertain the best approach for providing sedation and pain management for patients who have sustained trauma and are requiring respiratory support from a mechanical ventilator. The common approach to patients who need mechanical ventilation is to provide continuous drips of sedatives and pain medicine and awaken the patient once a day to check the brain functions. Another approach is to provide pain medicine and reserve sedatives for only a short duration when needed. The difference between approaches has not been studied in Trauma patients.

Analgesia-First Sedation in Trauma Patients

Analgesia-First Sedation in Trauma Patients

Condition
Mechanical Ventilation
Intervention / Treatment

-

Contacts and Locations

Long Beach

Long Beach Memorial Medical Center, Long Beach, California, United States, 90806

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. ≥ 18 years of age
  • 2. Mechanically ventilated with an expected duration of MV ≥ 48h
  • 3. Initiated continuous sedative/analgesic infusions by the ICU team
  • 4. Patient is a candidate for MV weaning
  • 1. Admission after resuscitation from cardiac arrest
  • 2. Significant neurological deficit due to a chronic disorder
  • 3. History of alcohol dependence and/or other illicit drug abuse
  • 4. Prior administration of continuous sedative/analgesic from a transferring institution
  • 5. Patient receiving neuromuscular blocking agents
  • 6. Allergy to midazolam, lorazepam, and/or propofol

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

MemorialCare Health System,

Study Record Dates

2025-09-01