RECRUITING

Moderate Versus High Volume Light-Moderate Intensity Exercise for People With Moderate Parkinson's Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Veterans with mid to later stage Parkinson's disease (PD) may not be able to work out as hard as they need to, to prevent brain cell loss. Maybe they could work out longer and more frequently to make up for this during their good times and good weeks and then rest during the bad weeks. The investigators will compare how effective working out a lot one week per month with a break of three weeks is to continuously exercising weekly with no breaks in people with mid stage PD. The investigators will look at how fast participants walk per minute, whether they become more physically active, the biochemicals in their blood, and at how stiff their blood vessels are before and after the exercise.

Official Title

Moderate Versus High Volume Light-Moderate Intensity Exercise for People With Moderate Parkinson's Disease

Quick Facts

Study Start:2025-01-25
Study Completion:2029-06-02
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06088355

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:40 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * MoCA score \>17
  2. * Able to walk with or without an assistive device at least 10 feet
  3. * Best corrected/aided acuity better than 20/70 in the better eye
  4. * Willingness to be randomized to a treatment group
  5. * H\&Y stages 2, 2.5 and 3
  6. * Show clear symptomatic benefit (e.g., alleviated rigidity, bradykinesia, and tremor) from antiparkinsonian medications
  7. * Fluent in English to be able to comprehend and participate; older than 40 years; Diagnosis of definite Parkinson's disease by board certified Movement Disorders Neurologist, using standardized UK Brain Bank criteria
  1. * Untreated Major Depression and major psychiatric illness
  2. * History of stroke, or traumatic brain injury
  3. * Pure-tone threshold average sensitivity at 0.5, 1.0,and 2.0 kHz exceeds 40 dB
  4. * Alcohol abuse and/or use of antipsychotics
  5. * Planning to leave the area for \>1 month during the study time period.
  6. * Taking moderate to high doses of beta-blockers with a resting heart rate below 60 beats/min given that exercise intensity is measured through target heart rate.
  7. * Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina
  8. * Other significant co-morbid disease that would impair ability to participate in the exercise-based intervention, e.g. renal failure on hemodialysis, excessive alcohol use (\>14 drinks per wk)

Contacts and Locations

Study Contact

Madeleine E Hackney, PhD
CONTACT
(404) 321-6111
mehackn@emory.edu
Joe R Nocera, PhD
CONTACT
(404) 321-6111
joenocera@emory.edu

Principal Investigator

Madeleine E. Hackney, PhD
PRINCIPAL_INVESTIGATOR
Atlanta VA Medical and Rehab Center, Decatur, GA

Study Locations (Sites)

Atlanta VA Medical and Rehab Center, Decatur, GA
Decatur, Georgia, 30033-4004
United States

Collaborators and Investigators

Sponsor: VA Office of Research and Development

  • Madeleine E. Hackney, PhD, PRINCIPAL_INVESTIGATOR, Atlanta VA Medical and Rehab Center, Decatur, GA

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-01-25
Study Completion Date2029-06-02

Study Record Updates

Study Start Date2025-01-25
Study Completion Date2029-06-02

Terms related to this study

Keywords Provided by Researchers

  • dance
  • walk
  • Neurodegenerative
  • aging
  • exercise
  • high volume
  • frequency
  • intensity
  • duration
  • biomarkers
  • Parkinson's disease

Additional Relevant MeSH Terms

  • Parkinson Disease
  • Movement Disorders
  • Neurodegeneration