Effect of Sleep Extension on Ceramides in People With Overweight and Obesity

Description

The overall goal is to determine how a sleep extension intervention (increasing time in bed) in individuals who maintain less than 6.5 hours sleep per night affects their plasma ceramides and insulin sensitivity. Participants will undergo a randomized controlled trial, with sleep extension (intervention) and healthy lifestyle (control) groups. The sleep extension is designed to increase participant's time in bed by 2 hours per night. Alternatively, the control group will receive basic health information (e.g., physical activity, goal setting, and nutrition when eating out).

Conditions

Lifestyle Factors, Overweight and Obesity, Insulin Sensitivity, Eating Habit, Sleep Hygiene, Type 2 Diabetes, Sleep, Sleep Deprivation, Insufficient Sleep Syndrome

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Study Overview

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Study Details

Study overview

The overall goal is to determine how a sleep extension intervention (increasing time in bed) in individuals who maintain less than 6.5 hours sleep per night affects their plasma ceramides and insulin sensitivity. Participants will undergo a randomized controlled trial, with sleep extension (intervention) and healthy lifestyle (control) groups. The sleep extension is designed to increase participant's time in bed by 2 hours per night. Alternatively, the control group will receive basic health information (e.g., physical activity, goal setting, and nutrition when eating out).

Biomarkers of Habitual Short Sleep and Related Cardiometabolic Risk

Effect of Sleep Extension on Ceramides in People With Overweight and Obesity

Condition
Lifestyle Factors
Intervention / Treatment

-

Contacts and Locations

Salt Lake City

College of Health Research Complex--University of Utah, Salt Lake City, Utah, United States, 84112

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Age: 18-45 years old; equal numbers of men and women
  • 2. Body mass index (BMI): 25.0-34.9 kg/m2
  • 3. Sleep Habits: habitual self-reported average total sleep time (TST) \<6.5 hours per night for prior 6 months
  • 1. Clinically diagnosed sleep disorder or major psychiatric illness
  • 2. Evidence of significant organ dysfunction or disease (e.g., heart disease, kidney disease)
  • 3. Clinically diagnosed diabetes or fasting plasma glucose ≥126 mg/dL or HbA1c ≥6.5%
  • 4. Use of prescription drugs or substances known to influence sleep or glucose metabolism, or anticoagulant medications.
  • 5. Cancer that has been in remission less than 5 years
  • 6. Pregnant/nursing, experiencing menopause or post-menopausal
  • 7. Shift-work: current or history of within last year
  • 8. Weight change: \>10% of body weight over prior six months
  • 9. Current enrollment in weight loss or physical activity program like the Diabetes Prevention Program
  • 10. Currently smoking
  • 11. Alcohol intake\>14 drinks per week or \>3 drinks per day

Ages Eligible for Study

18 Years to 45 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Utah,

Study Record Dates

2028-01