rTMS Over the Dorsolateral Prefrontal Cortex for the Treatment of Impulse Control Disorders in Parkinson's Disease

Description

This study's objective is to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC) of patients with Parkinson's Disease (PD) who experience impulse control disorders (ICDs) on impulse control symptoms and cognitive behaviors linked to ICDs: reinforcement learning and delay-discounting. This is a randomized sham-controlled cross-over trial. All patients will undergo a session of active rTMS and a session of sham rTMS, with the order of sessions randomized across participants. Following recruitment and eligibility screening, the eligible participants will undergo two sessions of rTMS (active and sham), immediately followed by neurocognitive tasks and questionnaires, no more than 1-2 weeks apart. Each session will have a duration of approximately 1-1.5 hours.

Conditions

Impulse Control Disorder, Parkinson Disease

Talk to us

Study Overview

On this page

Study Details

Study overview

This study's objective is to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC) of patients with Parkinson's Disease (PD) who experience impulse control disorders (ICDs) on impulse control symptoms and cognitive behaviors linked to ICDs: reinforcement learning and delay-discounting. This is a randomized sham-controlled cross-over trial. All patients will undergo a session of active rTMS and a session of sham rTMS, with the order of sessions randomized across participants. Following recruitment and eligibility screening, the eligible participants will undergo two sessions of rTMS (active and sham), immediately followed by neurocognitive tasks and questionnaires, no more than 1-2 weeks apart. Each session will have a duration of approximately 1-1.5 hours.

The Effects of High-Frequency Repetitive Transcranial Magnetic Stimulation on Impulse Control Disorders in Parkinson's Disease Patients on Dopamine Replacement Therapy.

rTMS Over the Dorsolateral Prefrontal Cortex for the Treatment of Impulse Control Disorders in Parkinson's Disease

Condition
Impulse Control Disorder
Intervention / Treatment

-

Contacts and Locations

Morgantown

West Virginia University Hospitals, Morgantown, West Virginia, United States, 26505

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Clinician-confirmed diagnosis of PD
  • * Ability to provide informed consent, written and verbal
  • * Clinician-diagnosed impulse control disorder or impulse control behaviors including punding/hobbyism and dopamine dysregulation syndrome
  • * A Beck Depression Inventory (BDI) (Beck et al., 1961) score of 14 or lower
  • * A Montreal Cognitive Assessment (MoCA) (Nasreddine et al., 2005) score of 20 or higher
  • * On dopamine-replacement therapy
  • * History of seizures or epilepsy
  • * History of brain lesions (such as multiple sclerosis, tumor) reported
  • * History of vascular issues in the brain, such as stroke
  • * History of a moderate to severe traumatic brain injury
  • * Meeting the criteria for a major psychiatric illness such as schizophrenia or depression (BDI score of 14 or higher).
  • * Having significant cognitive impairment (assessed by MoCA, cutoff score of 20) (Nasreddine, et al., 2005)
  • * Having had TMS done in the recent past (within a year)
  • * Pregnancy assessed in female patients
  • * Intracranial metallic objects (except for dental fillings)
  • * Current use of substances or medications known to significantly reduce seizure threshold.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

West Virginia University,

Mariya V Cherkasova, PhD, PRINCIPAL_INVESTIGATOR, West Virginia University

Study Record Dates

2025-02