Beta-Blocker Influences on Inflammatory and Neural Responses to Stress

Description

The purpose of this study is to map the neural and molecular mechanisms underlying psychological stress-induced changes in inflammation which could reveal new targets for intervention to reduce the risk of cardiovascular disease.

Conditions

Cardiovascular Disease

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Study Overview

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Study Details

Study overview

The purpose of this study is to map the neural and molecular mechanisms underlying psychological stress-induced changes in inflammation which could reveal new targets for intervention to reduce the risk of cardiovascular disease.

Beta-Blocker Influences on Inflammatory and Neural Responses to Stress

Beta-Blocker Influences on Inflammatory and Neural Responses to Stress

Condition
Cardiovascular Disease
Intervention / Treatment

-

Contacts and Locations

Chapel Hill

Social Neuroscience and Health Laboratory, Chapel Hill, North Carolina, United States, 27514

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Ages 18-30 years
  • * Right-handed
  • * Fluent in English reading, writing, and speaking at least at a 10th grade level
  • * Body mass index (BMI) less than or equal to 35 kg/m\^2
  • * Non-removeable metal devices/implants/objects in the body
  • * Severe claustrophobia (assessed by self-report)
  • * Currently pregnant
  • * Left-handed
  • * Body mass index (BMI) greater than 35 kg/m\^2
  • * History of fainting spells or any heart condition
  • * History of or present low resting heart rate (\< 60 BPM) and/or low blood pressure (systolic blood pressure \< 80mmHg)
  • * Self-reported physical illnesses: diabetes, cardiovascular diseases, high blood pressure, inflammatory bowel diseases, rheumatoid arthritis, asthma, autoimmune disease, Crohn's disease, ulcerative colitis, lupus
  • * Any self-reported diagnosed mental illness
  • * Current use of prescription medications
  • * Current or recent regular nicotine/tobacco use (cigarettes, e-cigarettes, vape, chewing tobacco, nicotine gum)
  • * Current regular (daily or almost daily) recreational drug use = 4 or more times per week
  • * Received any vaccine within the past two weeks
  • * Severe sleep disturbance (3-4 hours of sleep loss) the night before Session II
  • * Vigorous physical activity on the day of Session II
  • * Acute illness or allergy symptoms on the day of Session II
  • * Usage of over-the-counter medications on the day of Session II
  • * Usage of recreational drugs within 48 hours of Session II
  • * Usage of alcohol on the day of Session II

Ages Eligible for Study

18 Years to 30 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of North Carolina, Chapel Hill,

Keely Muscatell, PhD, PRINCIPAL_INVESTIGATOR, University of North Carolina, Chapel Hill

Study Record Dates

2026-05