COMPLETED

The Effects of an Acute High-intensity Exercise on Heart and Brain Function in People With Spinal Cord Injury

Conditions

Autonomic Nervous System Disease Spinal Cord Injuries Cognition

Quick Navigation

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The heart and brain are regulated by the autonomic nervous system. Control of these organs can be disrupted in people with spinal cord injury (SCI). This may affect their ability to regulate blood pressure during daily activities and process the high-level information. Previous studies show that high-intensity exercise induces better outcomes on heart and information processing ability in non-injured people compared to moderate-intensity exercise. However, it is unknown the effects of high-intensity exercise on heart and brain function in people with SCI. Therefore, this study aims to examine the effects of a single bout of high-intensity interval training on heart and brain function in this people with SCI compared to age- and sex-matched non-injured controls.

Official Title

The Effects of an Acute High-intensity Interval Training on Heart and Brain Function in People With Spinal Cord Injury

Quick Facts

Study Start:2024-02-14

Study Completion:2025-07-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:COMPLETED

Study ID

NCT06274658

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 70 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
1. Diagnosed with a traumatic or non-traumatic spinal cord injury and have ≥4/5 strength in at least one cervical 5 myotome (elbow flexors), allowing to utilize the arm ergometer and level of injury at or above the 6th thoracic vertebra 2. Classified as A, B, C, D (motor and sensory complete or incomplete) on the American Spinal Injury Association (ASIA) Impairment Scale (AIS) 3. Longer than 6 months post the onset of injury and have been discharged to the community from inpatient rehabilitation prior to enrollment 4. English is the first language 5. At least one of the cerebral arteries (i.e., middle cerebral artery and/or posterior cerebral artery) can be found via transcranial Doppler	1. Medical conditions that preclude exercise, such as unstable angina, uncontrolled arrhythmias, a recent history of congestive heart failure that has not been evaluated and effectively treated, severe valvular disease, uncontrolled hypertension (i.e., resting systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥ 105 mmHg) 2. Moderate-severe traumatic brain injury 3. Diabetes 4. Color blindness 5. Pre-existing shoulder injuries 6. Pregnancy

Inclusion Criteria

Exclusion Criteria

1. Diagnosed with a traumatic or non-traumatic spinal cord injury and have ≥4/5 strength in at least one cervical 5 myotome (elbow flexors), allowing to utilize the arm ergometer and level of injury at or above the 6th thoracic vertebra
2. Classified as A, B, C, D (motor and sensory complete or incomplete) on the American Spinal Injury Association (ASIA) Impairment Scale (AIS)
3. Longer than 6 months post the onset of injury and have been discharged to the community from inpatient rehabilitation prior to enrollment
4. English is the first language
5. At least one of the cerebral arteries (i.e., middle cerebral artery and/or posterior cerebral artery) can be found via transcranial Doppler

1. Medical conditions that preclude exercise, such as unstable angina, uncontrolled arrhythmias, a recent history of congestive heart failure that has not been evaluated and effectively treated, severe valvular disease, uncontrolled hypertension (i.e., resting systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥ 105 mmHg)
2. Moderate-severe traumatic brain injury
3. Diabetes
4. Color blindness
5. Pre-existing shoulder injuries
6. Pregnancy

Contacts and Locations

Principal Investigator

Wenjie Ji, MS

PRINCIPAL_INVESTIGATOR

University at Buffalo

Study Locations (Sites)

University at Buffalo, South Campus

Buffalo, New York, 14214

United States

Collaborators and Investigators

Sponsor: State University of New York at Buffalo

Wenjie Ji, MS, PRINCIPAL_INVESTIGATOR, University at Buffalo

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-02-14

Study Completion Date2025-07-31

Study Record Updates

Study Start Date2024-02-14

Study Completion Date2025-07-31

Terms related to this study

Additional Relevant MeSH Terms

Autonomic Nervous System Disease
Spinal Cord Injuries
Cognition