Sleep Health Enhancement in Midlife Adults

Description

Despite the strong links between sleep and AD, a sleep health enhancement has yet to be targeted in mid-life adults (45-64 years old) to delay or prevent AD. An intervention aimed at enhancing sleep health is a critical opportunity for primary prevention to potentially delay the onset of AD. The objective of the proposed study is to develop and assess the feasibility, acceptability, and treatment effect of a comprehensive sleep health intervention (SHI) on improving sleep health in mid-life adults

Conditions

Sleep Health, Midlife Adults

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Study Overview

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Study Details

Study overview

Despite the strong links between sleep and AD, a sleep health enhancement has yet to be targeted in mid-life adults (45-64 years old) to delay or prevent AD. An intervention aimed at enhancing sleep health is a critical opportunity for primary prevention to potentially delay the onset of AD. The objective of the proposed study is to develop and assess the feasibility, acceptability, and treatment effect of a comprehensive sleep health intervention (SHI) on improving sleep health in mid-life adults

Sleep Health Enhancement in Midlife Adults

Sleep Health Enhancement in Midlife Adults

Condition
Sleep Health
Intervention / Treatment

-

Contacts and Locations

Kansas City

University of Kansas Medical Center, Kansas City, Kansas, United States, 66160

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 45-64 years old
  • * ≤ 7 on the RU-SATED self-report questionnaire
  • * MMSE ≥25 and AD8 \<3
  • * Known untreated sleep disorder (such as sleep apnea or restless leg syndrome)
  • * \>3 on the STOP BANG indicating increased risk of sleep apnea
  • * Increased risk of restless legs syndrome on RLS-Diagnosis Index
  • * Evidence of circadian rhythm sleep-wake disorder
  • * Evidence of parasomnia
  • * Regular use (\>2x/week) of prescription or over-the-counter medications to improve sleep
  • * Score of ≥15 on the Patient Health Questionnaire (PHQ-9) indicating severe depression or endorsement of any suicidal ideation (answer 1, 2 or 3 on #9 of the PHQ-9)
  • * Score of ≥10 on the Generalized Anxiety Disorder (GAD-7) indicating moderate to severe anxiety
  • * Self-report of current or history (up to 2 years) of drug or alcohol abuse based on the DSM-5-TR criteria
  • * History of nervous system disorder such as stroke or Parkinson's disease
  • * Severe mental illness such as schizophrenia or bipolar disorder
  • * Current or history (within 5 years) of shift work including hours of midnight-4am
  • * Is currently receiving a behavioral sleep health intervention

Ages Eligible for Study

45 Years to 64 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Kansas Medical Center,

Study Record Dates

2025-06-30