COMPLETED

Targeting Chronic Stress for Reducing Risk Factors for Colorectal Cancer

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Many neighborhoods in Chicago experience daily exposure to stressors including economic inopportunity and violent crime in public spaces. There is mounting evidence that chronic psychosocial stress can facilitate carcinogenesis by modulating the gut microbiome and immune system. The proposed research aims to study the practice of mindfulness to mitigate CPS and reduce colorectal cancer risk factors among Black American women at elevated risk.

Official Title

Mindfulness and CRC Risk Factor Reduction: Targeting Chronic Stress For Colorectal Cancer Risk Factor Reduction A Pilot Feasibility Study Among Vulnerable At-Risk Black Females

Quick Facts

Study Start:2024-07-15
Study Completion:2025-08-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT06323421

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:45 Years to 65 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Female based on sex assigned at birth
  2. * Self-identify as Black
  3. * Age 45-65 years old
  4. * Completed a colonoscopy in the past 24 months,
  5. * Classify as elevated risk of CRC defined as: any colorectal adenoma detected in past 24 months
  6. * Own and use a smartphone, computer, or tablet with access to the Internet
  7. * Score ≥ 14 on the PSS at screening
  8. * Reside in a Chicago community with high violent crime
  1. * History of CRC
  2. * Antibiotics (oral/IV) in the past 2 months
  3. * Inflammatory bowel disease or genetic predisposition to CRC
  4. * Cancer diagnosis or cancer treatment in the past 12 months
  5. * Consume \> 50 grams of ethanol daily
  6. * Use combustible tobacco
  7. * Bariatric surgery or bowel resection
  8. * Immunodeficiency/autoimmune disease
  9. * Uncontrolled diabetes (HbA1c \> 9% based on EHR)
  10. * Fiber or pre-/probiotic supplements \> 3 days per week
  11. * Serrated adenoma at the recent colonoscopy given the molecular features are distinct
  12. * Significant health conditions or take medications that impact participation or expected outcomes (e.g., β-blocker, Cushing's syndrome, and corticosteroids - inhaled, topical, oral in the past month given effects on hair cortisol measurement)

Contacts and Locations

Study Locations (Sites)

University of Illinois Chicago
Chicago, Illinois, 60612
United States

Collaborators and Investigators

Sponsor: University of Illinois at Chicago

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-07-15
Study Completion Date2025-08-31

Study Record Updates

Study Start Date2024-07-15
Study Completion Date2025-08-31

Terms related to this study

Additional Relevant MeSH Terms

  • Mindfulness
  • Colon Cancer
  • Females