Intestinal Immunity in Neurologic Disease

Description

The purpose of this study is to ascertain the functional profiles of the immune cells within the gastrointestinal tract and to determine how these cells contribute to autoimmune and neurologic diseases.

Conditions

Multiple Sclerosis, Parkinson Disease, REM Sleep Behavior Disorder

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Study Overview

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Study Details

Study overview

The purpose of this study is to ascertain the functional profiles of the immune cells within the gastrointestinal tract and to determine how these cells contribute to autoimmune and neurologic diseases.

Intestinal Immunity in Neurologic Disease

Intestinal Immunity in Neurologic Disease

Condition
Multiple Sclerosis
Intervention / Treatment

-

Contacts and Locations

North Haven

Yale MS Clinic, North Haven, Connecticut, United States, 06473

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18 and up
  • * Recommended to under a screening colonoscopy (+/- upper endoscopy) as part of standard of care. This includes healthy individuals as well as those with neurologic and/or autoimmune diseases. OR
  • * Willing to undergo research colonoscopy (+/- upper endoscopy) for research
  • * Currently pregnant. Women of childbearing potential would perform a point of care urine pregnancy test prior to colonoscopy/endoscopy.
  • * Known or suspected, chronic inflammatory gastrointestinal disease (e.g. inflammatory bowel disease)
  • * Known, acute or chronic infections
  • * Systemic antibiotic (PO or IV) use within 3 months of colonoscopy
  • * Systemic corticosteroid use (equivalent of prednisone 10 mg per day or higher for \>5 days) within 2 weeks of colonoscopy
  • * Malignancy, diagnosed or treated within the last 5 years
  • * Probiotic use within 2 weeks of procedure
  • * History of major GI surgery (e.g. colon resection, gastric bypass)
  • * Bleeding disorder, or on anticoagulant medication
  • * Other medical condition that, in the judgement of the investigator, would lead to higher-than-expected risks of biopsy
  • * Allergy to MAC anesthesia or other drugs used pursuant to standard of care for biospecimen collection

Ages Eligible for Study

18 Years to 99 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Yale University,

Erin Longbrake, PRINCIPAL_INVESTIGATOR, Yale University

Study Record Dates

2027-08-31