RECRUITING

Genetics and Aerobic Exercise to Slow Parkinson's Disease Trial

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The proposed multi-site, Genetics and Aerobic Exercise to Slow PD (GEARS) Trial will, for the first time, determine the interplay between genetics and exercise in altering PD progression. In sum, 200 PD patients will be recruited from the Cleveland and Salt Lake City metro areas to participate in the Pedaling for Parkinson's (PFP) community-based exercise program. Participants will exercise at community-based sites 3x/week for 12 months. All participants will undergo genotyping using an array that includes the genome backbone and common risk variants associated to increase risk for multiple neurological disorders including PD.

Official Title

Genetics and Aerobic Exercise to Slow Parkinson's Disease (GEARS) Trial

Quick Facts

Study Start:2024-08-23
Study Completion:2028-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06442033

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Adult with a diagnosis of PD by a physician or physician extender
  2. 2. Hoehn and Yahr stage I-III
  3. 3. Demonstrate the ability to safely mount and dismount a stationary cycle
  4. 4. Reliable transportation to the community exercise facility
  5. 5. Smartphone device for activity data monitoring
  6. 6. On a stable dose of anti-parkinsonian medication
  1. 1. Participation in disease modifying PD-related clinical trial or study
  2. 2. Diagnosis of dementia or any neurocognitive impairment that compromises one's ability to provide informed consent.
  3. 3. Implanted deep brain stimulation electrodes or focused ultrasound for PD management
  4. 4. Recommendation for medical clearance using the American College of Sports Medicine (ACSM) Preparticipation Health Screen a. If the ACSM screen recommends medical clearance, the participant must obtain medical clearance by their health care provider prior to participation.

Contacts and Locations

Study Contact

Elizabeth Jansen, MPH
CONTACT
216-780-9160
jansena@ccf.org
Anson Rosenfeldt, DPT
CONTACT
216-644-7617
rosenfa2@ccf.org

Study Locations (Sites)

The Cleveland Clinic
Cleveland, Ohio, 44195
United States

Collaborators and Investigators

Sponsor: Jay Alberts

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-08-23
Study Completion Date2028-12-31

Study Record Updates

Study Start Date2024-08-23
Study Completion Date2028-12-31

Terms related to this study

Additional Relevant MeSH Terms

  • Parkinson Disease