Genetics and Aerobic Exercise to Slow Parkinson's Disease Trial

Description

The proposed multi-site, Genetics and Aerobic Exercise to Slow PD (GEARS) Trial will, for the first time, determine the interplay between genetics and exercise in altering PD progression. In sum, 200 PD patients will be recruited from the Cleveland and Salt Lake City metro areas to participate in the Pedaling for Parkinson's (PFP) community-based exercise program. Participants will exercise at community-based sites 3x/week for 12 months. All participants will undergo genotyping using an array that includes the genome backbone and common risk variants associated to increase risk for multiple neurological disorders including PD.

Conditions

Parkinson Disease

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Study Overview

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Study Details

Study overview

The proposed multi-site, Genetics and Aerobic Exercise to Slow PD (GEARS) Trial will, for the first time, determine the interplay between genetics and exercise in altering PD progression. In sum, 200 PD patients will be recruited from the Cleveland and Salt Lake City metro areas to participate in the Pedaling for Parkinson's (PFP) community-based exercise program. Participants will exercise at community-based sites 3x/week for 12 months. All participants will undergo genotyping using an array that includes the genome backbone and common risk variants associated to increase risk for multiple neurological disorders including PD.

Genetics and Aerobic Exercise to Slow Parkinson's Disease (GEARS) Trial

Genetics and Aerobic Exercise to Slow Parkinson's Disease Trial

Condition
Parkinson Disease
Intervention / Treatment

-

Contacts and Locations

Cleveland

The Cleveland Clinic, Cleveland, Ohio, United States, 44195

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Adult with a diagnosis of PD by a physician or physician extender
  • 2. Hoehn and Yahr stage I-III
  • 3. Demonstrate the ability to safely mount and dismount a stationary cycle
  • 4. Reliable transportation to the community exercise facility
  • 5. Smartphone device for activity data monitoring
  • 6. On a stable dose of anti-parkinsonian medication
  • 1. Participation in disease modifying PD-related clinical trial or study
  • 2. Diagnosis of dementia or any neurocognitive impairment that compromises one's ability to provide informed consent.
  • 3. Implanted deep brain stimulation electrodes or focused ultrasound for PD management
  • 4. Recommendation for medical clearance using the American College of Sports Medicine (ACSM) Preparticipation Health Screen a. If the ACSM screen recommends medical clearance, the participant must obtain medical clearance by their health care provider prior to participation.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Jay Alberts,

Study Record Dates

2028-12-31