RECRUITING

Pathways Mediating Impaired Postural Control in Parkinson's Disease

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this project is to use transcranial magnetic stimulation (TMS) to explore the state of excitability of corticocortical and corticofugal (cortex to spinal cord, cortex to brainstem to spinal cord) pathways that project to muscles that control the legs and trunk in people with Parkinson's disease. The outcome variables will be further analyzed to understand their relationship to quantitative measures of postural instability and gait dysfunction. As such, the project can be classified as basic physiologic research. The protocol is not designed to determine if measures of corticocortical or corticofugal excitability can be used as a biomarker to predict disease progression.

Official Title

Pathways Mediating Impaired Postural Control in Parkinson's Disease

Quick Facts

Study Start:2024-06-01

Study Completion:2027-06-10

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06464029

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:45 Years to 80 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Diagnosis of idiopathic PD or dystonia as determined by a movement disorders neurologist in accordance with the UK Society Brain Bank diagnostic criteria. * Age 45-80 years. * Able to ambulate independently without the use of an assistive device (e.g. cane) for 50 meters. * Age 45-80 years (this group will be age and sex-matched to the PD group) * Able to ambulate independently without the use of an assistive device (cane or walker) * Age 21-44 years (this group will be age and sex-matched to the PD group) * Able to ambulate independently without the use of an assistive device (cane or walker)	* Subjects who describe a history of a frequent vasovagal syncope (fainting) in response to blood, emotional stress, or sensory triggers. * Subjects who are on anti-coagulant medications. * Any musculoskeletal disorder that affects the ability to stand. * History of seizures, epilepsy, stroke, multiple sclerosis, or traumatic brain injury. * Intracranial metallic or magnetic devices. * Pacemaker or any implanted device. * History of surgery on blood vessels, brain or heart. * Unexplained, recurring headaches or concussion within the last six months. * Moderate to severe hearing impairment. * Subjects who are pregnant. * Dementia diagnosis * Other significant neurological disorders that may affect participation or performance in the study * Implanted deep brain stimulator or other neurosurgeries to treat PD.

Inclusion Criteria

Exclusion Criteria

* Diagnosis of idiopathic PD or dystonia as determined by a movement disorders neurologist in accordance with the UK Society Brain Bank diagnostic criteria.
* Age 45-80 years.
* Able to ambulate independently without the use of an assistive device (e.g. cane) for 50 meters.
* Age 45-80 years (this group will be age and sex-matched to the PD group)
* Able to ambulate independently without the use of an assistive device (cane or walker)
* Age 21-44 years (this group will be age and sex-matched to the PD group)
* Able to ambulate independently without the use of an assistive device (cane or walker)

* Subjects who describe a history of a frequent vasovagal syncope (fainting) in response to blood, emotional stress, or sensory triggers.
* Subjects who are on anti-coagulant medications.
* Any musculoskeletal disorder that affects the ability to stand.
* History of seizures, epilepsy, stroke, multiple sclerosis, or traumatic brain injury.
* Intracranial metallic or magnetic devices.
* Pacemaker or any implanted device.
* History of surgery on blood vessels, brain or heart.
* Unexplained, recurring headaches or concussion within the last six months.
* Moderate to severe hearing impairment.
* Subjects who are pregnant.
* Dementia diagnosis
* Other significant neurological disorders that may affect participation or performance in the study
* Implanted deep brain stimulator or other neurosurgeries to treat PD.

Contacts and Locations

Study Contact

Joshua De Kam

CONTACT

612-626-8052

jadekam@umn.edu

Principal Investigator

Colum MacKinnon, MD

PRINCIPAL_INVESTIGATOR

University of Minnesota

Study Locations (Sites)

University of Minnesota

Minneapolis, Minnesota, 55455

United States

Collaborators and Investigators

Sponsor: University of Minnesota

Colum MacKinnon, MD, PRINCIPAL_INVESTIGATOR, University of Minnesota

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-06-01

Study Completion Date2027-06-10

Study Record Updates

Study Start Date2024-06-01

Study Completion Date2027-06-10

Terms related to this study

Additional Relevant MeSH Terms

Parkinson Disease