COMPLETED

A Phase 1 Dose Escalation Study of VX-973 in Healthy Participants

Conditions

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of the study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple doses of VX-973 in healthy participants.

Official Title

A Phase 1, Randomized, Double-blind, Placebo-controlled, Single- and Multiple-dose Escalation Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of VX-973 in Healthy Adults

Quick Facts

Study Start:2024-09-30
Study Completion:2025-07-21
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT06615570

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 55 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Body mass index (BMI) of 18.0 to 32.0 kilogram per meter square (kg/m\^2)
  2. * A total body weight of more than (\>) 50 kg
  3. * Participants of non-childbearing potential
  4. * Nonsmoker or ex-smoker for at least 3 months before screening
  1. * History of febrile illness or other acute illness that has not fully resolved within 14 days before the first dose of study drug
  2. * Any condition possibly affecting drug absorption, distribution, metabolism, or excretion

Contacts and Locations

Study Locations (Sites)

ICON Salt Lake City
Salt Lake City, Utah, 84124
United States

Collaborators and Investigators

Sponsor: Vertex Pharmaceuticals Incorporated

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-09-30
Study Completion Date2025-07-21

Study Record Updates

Study Start Date2024-09-30
Study Completion Date2025-07-21

Terms related to this study

Additional Relevant MeSH Terms

  • Pain