RECRUITING

Nitrous Oxide Neuroimaging

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose nitrous oxide. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will occur over 2 visits and involves no long-term follow up.

Official Title

Functional MRI of Nitrous Oxide Inhalation in Volunteer Subjects

Quick Facts

Study Start:2025-01-13
Study Completion:2026-01-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06702631

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 59 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * have none of the specific exclusion criteria
  2. * have a valid email address and valid phone number throughout the study
  3. * free from any non-MRI compatible implants
  1. * are pregnant or attempting to conceive
  2. * body mass index (BMI) \> 35
  3. * significant memory impairment or hearing loss
  4. * sleep apnea
  5. * chronic pain or frequently taking pain medication (including tramadol)
  6. * any severe or poorly-controlled medical problem (hypertension, diabetes)
  7. * neurologic or psychiatric disease, including anxiety, and depression
  8. * severe cardiac disease
  9. * history of methylenetetrahydrofolate reductase (MTHFR) deficiency or variant mutation, as assessed by personal report
  10. * recent ear or eye surgery
  11. * being claustrophobic
  12. * have metal implants or non-removable metal piercings
  13. * having a history of adverse reaction to anesthetics
  14. * daily alcohol or heavy alcohol use; history of alcohol abuse
  15. * current daily smoker
  16. * regular or recent marijuana use (including prescribed/medical marijuana)
  17. * illicit drug use, i.e., street drugs
  18. * regularly taking: antiepileptics, antidepressants, anti-psychotics, antihistamines, anti-anxiety medication, stimulants, or sleep-aids

Contacts and Locations

Study Contact

Keith M Vogt, MD, PhD
CONTACT
4126473147
kev18@pitt.edu

Study Locations (Sites)

University of Pittsburgh
Pittsburgh, Pennsylvania, 15213
United States

Collaborators and Investigators

Sponsor: Keith M Vogt

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-01-13
Study Completion Date2026-01-01

Study Record Updates

Study Start Date2025-01-13
Study Completion Date2026-01-01

Terms related to this study

Additional Relevant MeSH Terms

  • Anesthesia
  • Pain
  • Amnesia