Evaluating Tolerability of ePUHRT With Brachytherapy Boost

Description

The purpose of this study is to evaluate the tolerability and toxicity of combining two radiation therapy methods for prostate cancer: Elective Pelvic Ultra Hypofractionated Irradiation Treatment (ePUHRT), which is an external beam radiotherapy with High Dose Rate Brachytherapy Boost (form of internal radiation where a cancer doctor implants a small plastic tube or balloon (catheter) in the tumor).

Conditions

Prostate Cancer

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Study Overview

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Study Details

Study overview

The purpose of this study is to evaluate the tolerability and toxicity of combining two radiation therapy methods for prostate cancer: Elective Pelvic Ultra Hypofractionated Irradiation Treatment (ePUHRT), which is an external beam radiotherapy with High Dose Rate Brachytherapy Boost (form of internal radiation where a cancer doctor implants a small plastic tube or balloon (catheter) in the tumor).

Evaluating Tolerability of Elective Pelvic Ultra Hypofractionated Irradiation Treatment (ePUHRT) With High Dose Rate Brachytherapy Boost for Unfavorable and Higher Risk Prostate Cancer

Evaluating Tolerability of ePUHRT With Brachytherapy Boost

Condition
Prostate Cancer
Intervention / Treatment

-

Contacts and Locations

Indianapolis

Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana, United States, 46202

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. ≥ 18 years old at the time of informed consent
  • 2. Capable of providing informed consent and HIPAA authorization
  • 3. Karnofsky performance score ≥ 70
  • 4. Pathologically confirmed unfavorable intermediate, high, and very high-risk prostate cancer per treating physician
  • 5. Candidate plans to undergo the standard of care prostate high dose brachytherapy boost procedure
  • 6. Up to date colon cancer screen per per American Cancer Society guidelines
  • 1. Prior pelvic irradiation treatment
  • 2. Prior rectal surgery which precludes instrumentation with rectal ultrasound probe.
  • 3. Evidence of nodal or distant disease on screening diagnostic work up.
  • 4. Prior prostatectomy, Holmium laser enucleation of the prostate or transurethral resection of the prostate procedure
  • 5. International Prostate Symptom Score (IPSS) score \> 16 despite medical therapy

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

MALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Indiana University,

Omar Ishaq, MD, PRINCIPAL_INVESTIGATOR, Indiana University Simon Comprehensive Cancer Center

Study Record Dates

2028-10