Magnesium-L-Threonate for Sleep Quality Post-Arthroplasty

Description

The study team is conducting a study to see if Magnesium-L-Threonate (MgT) can help improve how well participants sleep and reduce pain after total joint replacement surgery

Conditions

Sleep, Knee Osteoarthritis

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Study Overview

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Study Details

Study overview

The study team is conducting a study to see if Magnesium-L-Threonate (MgT) can help improve how well participants sleep and reduce pain after total joint replacement surgery

Use of Magnesium-L-Threonate to Improve Subjective Sleep Quality After Total Joint Arthroplasties: Randomized Controlled Clinical Trial

Magnesium-L-Threonate for Sleep Quality Post-Arthroplasty

Condition
Sleep
Intervention / Treatment

-

Contacts and Locations

Miami

University of Miami Hospital, Miami, Florida, United States, 33136

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients undergoing primary total knee or hip arthroplasty at the University of Miami Hospital
  • * Patients \> 18 years of age
  • * Subjects must be capable of providing informed consent
  • * English or Spanish-speaking
  • * Previous total joint arthroplasty at the surgical site
  • * History of sleeping disorders, including narcolepsy, sleep apnea, insomnia, parasomnias, and restless leg syndrome.
  • * History of Complex Regional Pain Syndrome in ipsilateral extremity
  • * History of demyelinating disorder or neurologic deficit in the affected extremity
  • * History of psychiatric disorders that could impact sleep, such as untreated depression, bipolar disorder, or schizophrenia.
  • * Participants taking medications known to cause significant sedation or insomnia.
  • * Pregnant or breastfeeding
  • * Being treated for a diagnosis other than primary osteoarthritis (e.g. pelvic/femur fracture)
  • * Patients with known substance use disorder within 6 months of surgery
  • * Liver Failure, via clinical diagnosis or international normalized ratio greater than 1.5 or Prothrombin time greater than 40
  • * Chronic Kidney Disease or glomerular filtration rate less than 30 mL/min

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Miami,

Victor H Hernandez, MD, PRINCIPAL_INVESTIGATOR, University of Miami

Study Record Dates

2026-05-01