RECRUITING

OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events

Description

The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants at risk for a first major cardiovascular event with elevated lipoprotein(a) (Lp\[a\]).

Study Overview

Study Details

Study overview

The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants at risk for a first major cardiovascular event with elevated lipoprotein(a) (Lp\[a\]).

A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing Olpasiran Use to Prevent First Major Cardiovascular Events in Participants With Elevated Lipoprotein(a)

OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events

Condition
Cardiovascular Disease
Intervention / Treatment

-

Contacts and Locations

Alexander City

Advanced Cardiovascular LLC, Alexander City, Alabama, United States, 35010

Fairhope

Eastern Shore Research Institute, Fairhope, Alabama, United States, 36532

Huntsville

Heart Center Research LLC, Huntsville, Alabama, United States, 35801

Mobile

CB Flock Research Corporation, Mobile, Alabama, United States, 36608

Tucson

Eclipse Clinical Research, Tucson, Arizona, United States, 85745

Inglewood

310 Clinical Research, Inglewood, California, United States, 90301

Northridge

Valley Clinical Trials, Northridge, California, United States, 91325

Roseville

Clinical Trials Research - Sacramento, Roseville, California, United States, 95661

San Diego

Acclaim Clinical Research, San Diego, California, United States, 92120

Walnut Creek

Diablo Clinical Research, Walnut Creek, California, United States, 94598

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age ≥50 years
  • * Lp(a)≥ 200 nmol/L during screening
  • * Multiple atherosclerotic cardiovascular disease risk factors, and/or evidence of atherosclerosis
  • * Prior acute atherothrombotic event (myocardial infarction, stroke, transient ischemic attack, acute limb ischemia)
  • * Prior or planned arterial revascularization
  • * History of major bleeding disorder

Ages Eligible for Study

50 Years to 105 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Amgen,

MD, STUDY_DIRECTOR, Amgen

Study Record Dates

2031-10-18