Treatment Trials

30 Clinical Trials for Various Conditions

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ENROLLING_BY_INVITATION
Post-market Clinical Follow-up Study of Alcon TOTAL30® Contact Lenses (Lehfilcon A)
Description

The purpose of this Post-Market Clinical Follow-Up (PMCF) study is to continuously assess the visual performance and safety of TOTAL30 Sphere and TOTAL30 for Astigmatism contact lenses in a real-world setting across a broad variety of patients through routine clinical practices.

COMPLETED
Comparison of Clinical Performance of Two Monthly Replacement Toric Soft Contact Lenses
Description

The purpose of this study is to assess the clinical performance of TOTAL30 for Astigmatism (T30fA) soft contact lenses with Biofinity Toric soft contact lenses.

COMPLETED
Clinical Performance Evaluation of Two Frequent Replacement Silicone Hydrogel Toric Contact Lenses
Description

The primary objective of this study is to evaluate the axis orientation of LID226397 toric contact lenses.

COMPLETED
Evaluation of Monthly Replacement Lenses in Habitual Soft Contact Lens Wearers Who Report Frequent Digital Devise Use
Description

To evaluate the clinical performance of two monthly silicone hydrogel contact lenses in habitual wearers of frequent replacement (FRP) lenses when worn for 1-month.

Conditions
COMPLETED
Apioc Contact Lens Feasibility
Description

This clinical trial will document the feasibility of the Apioc lens design by assessing which lens shape parameters yield successful on-eye-fit and movement of the Apioc contact lens design and evaluate the subjectively-reported comfort of the Apioc contact lens design.

COMPLETED
The Effects of Contact Lenses With Experimental Dye on Visual Function
Description

This is a single-site, two-visit, contralateral, non-dispensing, randomized, controlled and subject-masked study to measure potential benefits of the new UV blocker.

Conditions
COMPLETED
Clinical Characterization of Symptomatic Populations
Description

This is an unmasked, non-randomized, single arm, stratified, dispensing investigation of symptomatic and asymptomatic subject populations. Subjects will be assigned to a single study lens type to be worn bilaterally for approximately 4 weeks followed by no contact lens wear for 1 week.

Conditions
COMPLETED
Dispensing Study for the Phenacite Project
Description

Dispensing Study for the Phenacite Project. The investigational test lens was not the final optical design and the study was not used for design validation.

Conditions
COMPLETED
Evaluation of Investigational (Frequent Replacement) FRP Lens for Daily Wear
Description

The purpose of the study is to compare the investigational contact lens to a marketed contact lens. The study results were not used for design validation of investigational contact lens,

Conditions
COMPLETED
Evaluation of Enfilcon A Soft Contact Lens When Compared to Galyfilcon A Soft Contact Lens
Description

The primary objective of thes study is to confirm that the ocular response to the Test lenses are similar to those of the Control lenses when used in a 1 week planned replacement, daily wear modality over a 1-month period.

Conditions
COMPLETED
Safety and Acceptability of Using a Rewetting Drop With Contact Lens Wear
Description

Testing the Safety and Acceptability of Using a Rewetting Drop with Contact Lenses

Conditions
COMPLETED
Comparison of Two Toric Contact Lenses on Current Toric Wearers
Description

The purpose of this study is to evaluate and compare the clinical performance of two toric contact lenses amongst 110 subjects, 2-week, single masked (subject), daily wear, randomized, bilateral, crossover study; 4 weeks duration. Hypotheses include equal or better performance of the test lens over the control lenses for comfort, vision, and toric fit characteristics as well as corneal integrity

Conditions
COMPLETED
Study of Soft Contact Lens Use With 7 Day Extended Wear
Description

To compare the safety and efficacy of the CVI silicone-hydrogel lens worn on an extended wear basis for a period of up to 7 days and 6 nights with the Acuvue 2 soft contact lenses.

Conditions
COMPLETED
1-Week Dispensing Evaluation of REVIVE™ Toric Soft Contact Lenses
Description

Experienced soft contact lens wearing subjects will be enrolled in this 1-week, post-market, bilateral, repeated measures, dispensing study. All subjects will be seen for a Screening/Dispensing Visit at which informed consent will be obtained and eligibility will be assessed. If subjects satisfy all eligibility criteria and none of the exclusion criteria, subjects will be fit and dispensed study lenses. If unsuccessful in the dispensed lenses, additional lenses may be trialed. Once vision and lens fit are determined to be acceptable, eligible subjects will wear study lenses in both eyes for at least 8 hours per day (with the exception of the follow-up visits where the lenses should be worn for a minimum of 2 hours), for approximately 1 week (7 days +/-3 days). Measurements will be taken at the insertion visit and at the 7-day follow-up visit.

COMPLETED
Air Optix Night and Day Aqua (AONDA) Retrospective Study 1
Description

The purpose of this study is to assess long term performance and safety of AONDA in a real world setting when worn as daily wear or continuous wear for vision correction. This study will be used to support AONDA's marketability in Europe and other locations.

COMPLETED
The Clinical Performance of Two Reusable Silicone Hydrogel Contact Lenses
Description

The purpose of this study is to assess the clinical performance of two reusable silicone hydrogel contact lenses when worn on a daily wear basis.

COMPLETED
Clinical Evaluation of a Manufacturing Process for a Frequent Replacement Silicone Hydrogel Multifocal Contact Lens
Description

The purpose of this clinical trial was to evaluate the clinical performance of a manufacturing process on a frequent replacement multifocal contact lens.

COMPLETED
A Study to Evaluate the Safety and Effectiveness of a Contact Lens Cleaning and Disinfecting Solution
Description

Approximately 340 participants (680 eyes) will be enrolled in this three-month, two-arm, 1:1 randomized, parallel-group, bilateral, double-masked study at approximately 22 investigative sites in the United States. Participants will be required to wear dispensed study lenses on a daily wear basis for three months with scheduled in-office replacement of study lenses at the 1-Month and 2-Month Follow-Up Visits.

COMPLETED
Assessment of an Investigational Frequent Replacement Silicone Hydrogel Lens
Description

The purpose of this clinical trial is to evaluate the safety and performance of an investigational soft contact lens compared to a commercially available soft contact lens when worn in an extended wear modality.

COMPLETED
Comparison of Two Daily Disposable Lenses
Description

The purpose of this study was to compare the clinical performance of the new DAILIES® AquaComfort PLUS® FreshTech (DACP FreshTech) contact lenses to an already marketed daily disposable contact lens, DAILIES® AquaComfort PLUS® (DACP).

COMPLETED
Dispensing Evaluation of Subjective Comfort, Vision, and Handling of a New Lens Compared to a Marketed Lens
Description

To evaluate and compare the performance of a new contact lens to a marketed contact lens.

COMPLETED
Evaluation of the Performance of Two Contact Lenses Compared to a Marketed Lens
Description

This study will serve to evaluate and compare the performance of two new lenses to a marketed lens.

RECRUITING
North American Comfilcon A Clinical Study
Description

The main objective of this study is to demonstrate acceptable safety and effectiveness (performance) of comfilcon A Sphere, Toric, Multifocal, Toric Multifocal and Energys lenses, when used in the general population.

COMPLETED
Clinical Comparison of Two Daily Disposable Toric Soft Contact Lenses
Description

The primary purpose of this study is to demonstrate noninferiority in the visual acuity at distance when wearing PRECISION1™ for Astigmatism (P1fA) soft contact lenses compared to another commercially available, soft toric contact lens, MyDay® toric (MDT).

COMPLETED
Clinical Performance of Two Commercial, Daily Disposable Contact Lenses
Description

The purpose of this study is to compare the clinical performance of DAILIES TOTAL1 ( DT1) contact lenses with Infuse contact lenses.

COMPLETED
Clinical Comparison of Two Daily Disposable Contact Lenses - Pilot Study 3
Description

The purpose of this study is to evaluate the overall performance of PRECISION1™ contact lenses when compared to INFUSE™ contact lenses.

Conditions
COMPLETED
Clinical Performance of Two Daily Disposable Toric Soft Contact Lenses
Description

The purpose of this study is to compare the clinical performance of PRECISION1™ for Astigmatism (P1fA) contact lenses with 1-DAY ACUVUE MOIST® for ASTIGMATISM (AMfA) contact lenses.

COMPLETED
Comparing Vision Tests in a Virtual Reality Headset to Existing Analogues
Description

The purpose of this study is to compare the results of vision tests that are algorithmically derived and delivered through a virtual reality headset with those delivered through the existing technology standards (eg. Humphrey for field tests). Tests that the researchers will be conducting include vision field perimetry, Amsler, acuity chart, contrast- sensitivity and currently used office tests.

COMPLETED
Clinical Comparison of Two Daily Wear Frequent Replacement Silicone Hydrogel Soft Contact Lenses
Description

The primary objective of this study is to evaluate the overall performance of an investigational silicone hydrogel lens when compared to ACUVUE OASYS® with HYDRACLEAR® PLUS (AOHP).

COMPLETED
Clinical Biocompatibility Evaluation of Contact Lens Coatings
Description

The primary objective is to evaluate corneal staining observed after 2 hours of wear with contact lenses with investigational coating against PureVision™ lenses, all pre-cycled with OPTI-FREE® RepleniSH® multi-purpose disinfection solution.